Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide

Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide

Zinc‐chronized gelling: Selective zinc‐triggered hydrogel formation is realized by the self‐assembly of a de novo designed peptide (see picture). A non‐natural, zinc‐binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation....

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Veröffentlicht in:Angewandte Chemie (International ed.) 2011-02, Vol.50 (7), p.1577-1579
Hauptverfasser: Micklitsch, Christopher M, Knerr, Patrick J, Branco, Monica C, Nagarkar, Radhika, Pochan, Darrin J, Schneider, Joel P
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Circular Dichroism
hydrogels
Hydrogels - chemistry
Inverted Repeat Sequences
materials
Molecular Sequence Data
peptides
Peptides - chemistry
Protein Structure, Secondary
self-assembly
zinc
Zinc - chemistry
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Beschreibung
Zusammenfassung:Zinc‐chronized gelling: Selective zinc‐triggered hydrogel formation is realized by the self‐assembly of a de novo designed peptide (see picture). A non‐natural, zinc‐binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201006652