Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program

Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program

Apparent treatment-resistant hypertension (ATRH) has been linked to end-stage kidney disease (ESKD) and cardiovascular disease. We tested the hypothesis that the effect of ATRH on ESKD is greater in Black patients than in White patients and investigated the effect of ATRH on ESKD independent of APOL...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2021-08, Vol.78 (2), p.376-386
Hauptverfasser: Akwo, Elvis A., Robinson-Cohen, Cassianne, Chung, Cecilia P., Shah, Shailja C., Brown, Nancy J., Ikizler, T. Alp, Wilson, Otis D., Rowan, Bryce X., Shuey, Megan M., Siew, Edward D., Luther, James M., Giri, Ayush, Hellwege, Jacklyn N., Velez Edwards, Digna R., Roumie, Christianne L., Tao, Ran, Tsao, Phil S., Gaziano, J. Michael, Wilson, Peter W.F., O’Donnell, Christopher J., Edwards, Todd L., Kovesdy, Csaba P., Hung, Adriana M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antihypertensive Agents - therapeutic use
Apolipoprotein L1 - genetics
Blood Pressure - physiology
Comorbidity
Female
Genetic Predisposition to Disease
Genotype
Humans
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - genetics
Incidence
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - genetics
Male
Middle Aged
Myocardial Infarction - epidemiology
Myocardial Infarction - genetics
Retrospective Studies
Veterans
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Zusammenfassung:Apparent treatment-resistant hypertension (ATRH) has been linked to end-stage kidney disease (ESKD) and cardiovascular disease. We tested the hypothesis that the effect of ATRH on ESKD is greater in Black patients than in White patients and investigated the effect of ATRH on ESKD independent of APOL1 genotype. In a retrospective cohort of 139 685 hypertensive veterans (22% Black, 5% women) in the Million Veteran Program, ATRH was defined as failure to achieve outpatient blood pressure
ISSN:0194-911X
1524-4563
1524-4563
DOI:10.1161/HYPERTENSIONAHA.120.16181