Morphological and functional alterations in endothelial colony-forming cells from recovered COVID-19 patients

Morphological and functional alterations in endothelial colony-forming cells from recovered COVID-19 patients

•COVID-19 is associated with vascular endothelial damage and thrombosis.•ECFCs from recovered COVID-19 patients are abnormal and have no proliferative capacity.•Plasma from COVID-19 patients induces dysfunction of ECFCs obtained from controls and VTD patients.•Our date may help to explain the increa...

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Veröffentlicht in:Thrombosis research 2021-10, Vol.206, p.55-59
Hauptverfasser: Alvarado-Moreno, José Antonio, Davila-Moreno, Jorge, Dominguez-Reyes, Victor, Arreola-Diaz, Rodrigo, Isordia-Salas, Irma, Chavez-Gonzalez, Antonieta, Majluf-Cruz, Abraham
Format: Artikel
Sprache:eng
Schlagworte:
Cell Proliferation
COVID-19
Endothelial cell dysfunction
Endothelial Cells
Endothelial Colony-Forming Cells
Humans
SARS-CoV-2
Thrombosis
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Zusammenfassung:•COVID-19 is associated with vascular endothelial damage and thrombosis.•ECFCs from recovered COVID-19 patients are abnormal and have no proliferative capacity.•Plasma from COVID-19 patients induces dysfunction of ECFCs obtained from controls and VTD patients.•Our date may help to explain the increased frequency of thrombotic episodes in COVID-19 patients.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2021.08.007