Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization....
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| Veröffentlicht in: | Trends in molecular medicine 2019-06, Vol.25 (6), p.464-466 |
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| creator | Nguyen, April H. Miller, William R. Arias, Cesar A. |
| description | Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance. |
| doi_str_mv | 10.1016/j.molmed.2019.04.011 |
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A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. 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| ispartof | Trends in molecular medicine, 2019-06, Vol.25 (6), p.464-466 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibiotic resistance Bile Acids and Salts - metabolism daptomycin Drug Resistance, Bacterial Enterococcus Enterococcus - cytology Enterococcus - drug effects Enterococcus - physiology Enterococcus faecium - drug effects Enterococcus faecium - physiology Gastroenteritis - metabolism Gastroenteritis - microbiology Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology GI colonization Gram-Positive Bacterial Infections - metabolism Gram-Positive Bacterial Infections - microbiology Humans Signal Transduction VRE |
| title | Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization |
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