Shape Follows Function: Gastrointestinal Signals for Enterococcal Colonization

Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization....

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Veröffentlicht in:	Trends in molecular medicine 2019-06, Vol.25 (6), p.464-466
Hauptverfasser:	Nguyen, April H., Miller, William R., Arias, Cesar A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibiotic resistance Bile Acids and Salts - metabolism daptomycin Drug Resistance, Bacterial Enterococcus Enterococcus - cytology Enterococcus - drug effects Enterococcus - physiology Enterococcus faecium - drug effects Enterococcus faecium - physiology Gastroenteritis - metabolism Gastroenteritis - microbiology Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology GI colonization Gram-Positive Bacterial Infections - metabolism Gram-Positive Bacterial Infections - microbiology Humans Signal Transduction VRE
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Zusammenfassung:	Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695–705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2019.04.011