Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
Household contacts of persons infected with SARS-CoV-2 are at risk for infection. A single subcutaneous injection of two anti–SARS-CoV-2 monoclonal antibodies in such persons within 4 days after the detection of infection in a household contact reduced this risk by two thirds in the first 28 days af...
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| Veröffentlicht in: | The New England journal of medicine 2021-09, Vol.385 (13), p.1184-1195 |
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| container_title | The New England journal of medicine |
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| creator | O’Brien, Meagan P Forleo-Neto, Eduardo Musser, Bret J Isa, Flonza Chan, Kuo-Chen Sarkar, Neena Bar, Katharine J Barnabas, Ruanne V Barouch, Dan H Cohen, Myron S Hurt, Christopher B Burwen, Dale R Marovich, Mary A Hou, Peijie Heirman, Ingeborg Davis, John D Turner, Kenneth C Ramesh, Divya Mahmood, Adnan Hooper, Andrea T Hamilton, Jennifer D Kim, Yunji Purcell, Lisa A Baum, Alina Kyratsous, Christos A Krainson, James Perez-Perez, Richard Mohseni, Rizwana Kowal, Bari DiCioccio, A. Thomas Stahl, Neil Lipsich, Leah Braunstein, Ned Herman, Gary Yancopoulos, George D Weinreich, David M |
| description | Household contacts of persons infected with SARS-CoV-2 are at risk for infection. A single subcutaneous injection of two anti–SARS-CoV-2 monoclonal antibodies in such persons within 4 days after the detection of infection in a household contact reduced this risk by two thirds in the first 28 days after exposure. |
| doi_str_mv | 10.1056/NEJMoa2109682 |
| format | Article |
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A single subcutaneous injection of two anti–SARS-CoV-2 monoclonal antibodies in such persons within 4 days after the detection of infection in a household contact reduced this risk by two thirds in the first 28 days after exposure.</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2109682</identifier><identifier>PMID: 34347950</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Antibodies ; Antibodies, Monoclonal, Humanized - therapeutic use ; Asymptomatic ; Asymptomatic Diseases ; Child ; Coronavirus ; Coronaviruses ; COVID-19 ; COVID-19 - prevention & control ; COVID-19 - virology ; COVID-19 Drug Treatment ; Disease transmission ; Double-Blind Method ; Drug Combinations ; Female ; Households ; Humans ; Incidence ; Infections ; Infectious Disease ; Injections, Subcutaneous ; Laboratories ; Male ; Middle Aged ; Monoclonal antibodies ; Original ; Patient Acuity ; Placebos ; Polymerase chain reaction ; Population ; Prevention ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Teenagers ; Viral Load ; Young Adult</subject><ispartof>The New England journal of medicine, 2021-09, Vol.385 (13), p.1184-1195</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><rights>Copyright © 2021 Massachusetts Medical Society. 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-09, Vol.385 (13), p.1184-1195 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8362593 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adolescent Adult Age Aged Aged, 80 and over Antibodies Antibodies, Monoclonal, Humanized - therapeutic use Asymptomatic Asymptomatic Diseases Child Coronavirus Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 - virology COVID-19 Drug Treatment Disease transmission Double-Blind Method Drug Combinations Female Households Humans Incidence Infections Infectious Disease Injections, Subcutaneous Laboratories Male Middle Aged Monoclonal antibodies Original Patient Acuity Placebos Polymerase chain reaction Population Prevention SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Statistical analysis Teenagers Viral Load Young Adult |
| title | Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19 |
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