Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

Household contacts of persons infected with SARS-CoV-2 are at risk for infection. A single subcutaneous injection of two anti–SARS-CoV-2 monoclonal antibodies in such persons within 4 days after the detection of infection in a household contact reduced this risk by two thirds in the first 28 days af...

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Veröffentlicht in:	The New England journal of medicine 2021-09, Vol.385 (13), p.1184-1195
Hauptverfasser:	O’Brien, Meagan P, Forleo-Neto, Eduardo, Musser, Bret J, Isa, Flonza, Chan, Kuo-Chen, Sarkar, Neena, Bar, Katharine J, Barnabas, Ruanne V, Barouch, Dan H, Cohen, Myron S, Hurt, Christopher B, Burwen, Dale R, Marovich, Mary A, Hou, Peijie, Heirman, Ingeborg, Davis, John D, Turner, Kenneth C, Ramesh, Divya, Mahmood, Adnan, Hooper, Andrea T, Hamilton, Jennifer D, Kim, Yunji, Purcell, Lisa A, Baum, Alina, Kyratsous, Christos A, Krainson, James, Perez-Perez, Richard, Mohseni, Rizwana, Kowal, Bari, DiCioccio, A. Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary, Yancopoulos, George D, Weinreich, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Antibodies Antibodies, Monoclonal, Humanized - therapeutic use Asymptomatic Asymptomatic Diseases Child Coronavirus Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 - virology COVID-19 Drug Treatment Disease transmission Double-Blind Method Drug Combinations Female Households Humans Incidence Infections Infectious Disease Injections, Subcutaneous Laboratories Male Middle Aged Monoclonal antibodies Original Patient Acuity Placebos Polymerase chain reaction Population Prevention SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Statistical analysis Teenagers Viral Load Young Adult
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Beschreibung
Zusammenfassung:	Household contacts of persons infected with SARS-CoV-2 are at risk for infection. A single subcutaneous injection of two anti–SARS-CoV-2 monoclonal antibodies in such persons within 4 days after the detection of infection in a household contact reduced this risk by two thirds in the first 28 days after exposure.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2109682