Gastro‑intestinal dysfunctions in Parkinson's disease (Review)
In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even m...
Gespeichert in:
| Veröffentlicht in: | Experimental and therapeutic medicine 2021-10, Vol.22 (4), Article 1083 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | |
| container_title | Experimental and therapeutic medicine |
| container_volume | 22 |
| creator | Ivan, Irina-Florina Irincu, Valentina-Laura Diaconu, Stefania Falup-Pecurariu, Oana Ciopleias, Bogdan Falup- Pecurariu, Cristian |
| description | In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess saliva accumulates in the mouth due to the low frequency of swallowing. Dysphagia develops in about 50% of patients and may be a reflection of both central nervous system and enteric nervous system disorder. Gastroparesis can cause a variety of symptoms, including nausea, and also may be responsible for some of the motor fluctuations observed with levodopa therapy. Intestinal dysfunction in PD may be the result of both delayed colon transit and impaired anorectal muscle coordination. In addition, recent studies have demonstrated the role of Helicobacter pylori infection in the pathogenesis of diseases but also the occurrence of motor fluctuations by affecting the absorption of anti-parkinsonian medication. In this review, the main gastrointestinal dysfunctions associated with PD are presented. |
| doi_str_mv | 10.3892/etm.2021.10517 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8355716</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A676649725</galeid><sourcerecordid>A676649725</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-13aa1e025c4ed61e0342c059d6a788df09aeede5cec1be79808c7aedbb03ee653</originalsourceid><addsrcrecordid>eNptUctOWzEQtSpQQcC26yt1ASwS_Lh-bRBRVAISElXVri3Hnpua5trUvknFjl_gF_kSnDaiQmJmMaOZM0dndBD6RPCYKU3PYOjHFFMyJpgT-QHtE6npiGDCd7Y91orsoaNS7nANLohS_CPaY23bylaKfXQxs2XI6fnxKcQByhCiXTb-oXSr6IaQYmlCbL7a_CvEkuJxaXwoYAs0J99gHeDP6SHa7eyywNG2HqAfl1--T69GN7ez6-nkZuSYpsOIMGsJYMpdC17UjrXUYa69sFIp32FtATxwB47MQWqFlZMW_HyOGYDg7ACd_-O9X8178A7ikO3S3OfQ2_xgkg3m7SaGn2aR1kYxziURleDzliCn36v6qrlLq1zfLYZyoVrNGGf_UQu7BBNilyqZ60NxZiKkEK2WdCNm_A6qpoc-uBShC3X-3oHLqZQM3atwgs3GS1O9NBsvzV8v2Qu3tZFi</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2568493353</pqid></control><display><type>article</type><title>Gastro‑intestinal dysfunctions in Parkinson's disease (Review)</title><source>PubMed Central</source><creator>Ivan, Irina-Florina ; Irincu, Valentina-Laura ; Diaconu, Stefania ; Falup-Pecurariu, Oana ; Ciopleias, Bogdan ; Falup- Pecurariu, Cristian</creator><creatorcontrib>Ivan, Irina-Florina ; Irincu, Valentina-Laura ; Diaconu, Stefania ; Falup-Pecurariu, Oana ; Ciopleias, Bogdan ; Falup- Pecurariu, Cristian</creatorcontrib><description>In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess saliva accumulates in the mouth due to the low frequency of swallowing. Dysphagia develops in about 50% of patients and may be a reflection of both central nervous system and enteric nervous system disorder. Gastroparesis can cause a variety of symptoms, including nausea, and also may be responsible for some of the motor fluctuations observed with levodopa therapy. Intestinal dysfunction in PD may be the result of both delayed colon transit and impaired anorectal muscle coordination. In addition, recent studies have demonstrated the role of Helicobacter pylori infection in the pathogenesis of diseases but also the occurrence of motor fluctuations by affecting the absorption of anti-parkinsonian medication. In this review, the main gastrointestinal dysfunctions associated with PD are presented.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2021.10517</identifier><identifier>PMID: 34447476</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Appetite ; Body mass index ; Causes of ; Complications and side effects ; Constipation ; Defecation ; Deglutition disorders ; Dementia ; Development and progression ; Dyskinesia ; Dysphagia ; Educational aspects ; Fecal incontinence ; Gastrointestinal diseases ; Helicobacter infections ; Infections ; Malnutrition ; Motility ; Osteoporosis ; Parkinson's disease ; Pathogenesis ; Patients ; Pharmacokinetics ; Pneumonia ; Quality of life ; Review ; Risk factors ; Vitamin deficiency</subject><ispartof>Experimental and therapeutic medicine, 2021-10, Vol.22 (4), Article 1083</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright © 2020, Spandidos Publications 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-13aa1e025c4ed61e0342c059d6a788df09aeede5cec1be79808c7aedbb03ee653</citedby><cites>FETCH-LOGICAL-c392t-13aa1e025c4ed61e0342c059d6a788df09aeede5cec1be79808c7aedbb03ee653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355716/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355716/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Ivan, Irina-Florina</creatorcontrib><creatorcontrib>Irincu, Valentina-Laura</creatorcontrib><creatorcontrib>Diaconu, Stefania</creatorcontrib><creatorcontrib>Falup-Pecurariu, Oana</creatorcontrib><creatorcontrib>Ciopleias, Bogdan</creatorcontrib><creatorcontrib>Falup- Pecurariu, Cristian</creatorcontrib><title>Gastro‑intestinal dysfunctions in Parkinson's disease (Review)</title><title>Experimental and therapeutic medicine</title><description>In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess saliva accumulates in the mouth due to the low frequency of swallowing. Dysphagia develops in about 50% of patients and may be a reflection of both central nervous system and enteric nervous system disorder. Gastroparesis can cause a variety of symptoms, including nausea, and also may be responsible for some of the motor fluctuations observed with levodopa therapy. Intestinal dysfunction in PD may be the result of both delayed colon transit and impaired anorectal muscle coordination. In addition, recent studies have demonstrated the role of Helicobacter pylori infection in the pathogenesis of diseases but also the occurrence of motor fluctuations by affecting the absorption of anti-parkinsonian medication. In this review, the main gastrointestinal dysfunctions associated with PD are presented.</description><subject>Appetite</subject><subject>Body mass index</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Constipation</subject><subject>Defecation</subject><subject>Deglutition disorders</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Dyskinesia</subject><subject>Dysphagia</subject><subject>Educational aspects</subject><subject>Fecal incontinence</subject><subject>Gastrointestinal diseases</subject><subject>Helicobacter infections</subject><subject>Infections</subject><subject>Malnutrition</subject><subject>Motility</subject><subject>Osteoporosis</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Pharmacokinetics</subject><subject>Pneumonia</subject><subject>Quality of life</subject><subject>Review</subject><subject>Risk factors</subject><subject>Vitamin deficiency</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUctOWzEQtSpQQcC26yt1ASwS_Lh-bRBRVAISElXVri3Hnpua5trUvknFjl_gF_kSnDaiQmJmMaOZM0dndBD6RPCYKU3PYOjHFFMyJpgT-QHtE6npiGDCd7Y91orsoaNS7nANLohS_CPaY23bylaKfXQxs2XI6fnxKcQByhCiXTb-oXSr6IaQYmlCbL7a_CvEkuJxaXwoYAs0J99gHeDP6SHa7eyywNG2HqAfl1--T69GN7ez6-nkZuSYpsOIMGsJYMpdC17UjrXUYa69sFIp32FtATxwB47MQWqFlZMW_HyOGYDg7ACd_-O9X8178A7ikO3S3OfQ2_xgkg3m7SaGn2aR1kYxziURleDzliCn36v6qrlLq1zfLYZyoVrNGGf_UQu7BBNilyqZ60NxZiKkEK2WdCNm_A6qpoc-uBShC3X-3oHLqZQM3atwgs3GS1O9NBsvzV8v2Qu3tZFi</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Ivan, Irina-Florina</creator><creator>Irincu, Valentina-Laura</creator><creator>Diaconu, Stefania</creator><creator>Falup-Pecurariu, Oana</creator><creator>Ciopleias, Bogdan</creator><creator>Falup- Pecurariu, Cristian</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Gastro‑intestinal dysfunctions in Parkinson's disease (Review)</title><author>Ivan, Irina-Florina ; Irincu, Valentina-Laura ; Diaconu, Stefania ; Falup-Pecurariu, Oana ; Ciopleias, Bogdan ; Falup- Pecurariu, Cristian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-13aa1e025c4ed61e0342c059d6a788df09aeede5cec1be79808c7aedbb03ee653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Appetite</topic><topic>Body mass index</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Constipation</topic><topic>Defecation</topic><topic>Deglutition disorders</topic><topic>Dementia</topic><topic>Development and progression</topic><topic>Dyskinesia</topic><topic>Dysphagia</topic><topic>Educational aspects</topic><topic>Fecal incontinence</topic><topic>Gastrointestinal diseases</topic><topic>Helicobacter infections</topic><topic>Infections</topic><topic>Malnutrition</topic><topic>Motility</topic><topic>Osteoporosis</topic><topic>Parkinson's disease</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Pharmacokinetics</topic><topic>Pneumonia</topic><topic>Quality of life</topic><topic>Review</topic><topic>Risk factors</topic><topic>Vitamin deficiency</topic><toplevel>online_resources</toplevel><creatorcontrib>Ivan, Irina-Florina</creatorcontrib><creatorcontrib>Irincu, Valentina-Laura</creatorcontrib><creatorcontrib>Diaconu, Stefania</creatorcontrib><creatorcontrib>Falup-Pecurariu, Oana</creatorcontrib><creatorcontrib>Ciopleias, Bogdan</creatorcontrib><creatorcontrib>Falup- Pecurariu, Cristian</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivan, Irina-Florina</au><au>Irincu, Valentina-Laura</au><au>Diaconu, Stefania</au><au>Falup-Pecurariu, Oana</au><au>Ciopleias, Bogdan</au><au>Falup- Pecurariu, Cristian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastro‑intestinal dysfunctions in Parkinson's disease (Review)</atitle><jtitle>Experimental and therapeutic medicine</jtitle><date>2021-10-01</date><risdate>2021</risdate><volume>22</volume><issue>4</issue><artnum>1083</artnum><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>In patients with Parkinson's disease (PD), gastrointestinal dysfunction occurs from the early stages of the disease and even in the pre-motor phase. This condition can include the entire digestive tract, with symptoms ranging from delays in gastric emptying to dysphagia, constipation and even malnutrition. Excess saliva accumulates in the mouth due to the low frequency of swallowing. Dysphagia develops in about 50% of patients and may be a reflection of both central nervous system and enteric nervous system disorder. Gastroparesis can cause a variety of symptoms, including nausea, and also may be responsible for some of the motor fluctuations observed with levodopa therapy. Intestinal dysfunction in PD may be the result of both delayed colon transit and impaired anorectal muscle coordination. In addition, recent studies have demonstrated the role of Helicobacter pylori infection in the pathogenesis of diseases but also the occurrence of motor fluctuations by affecting the absorption of anti-parkinsonian medication. In this review, the main gastrointestinal dysfunctions associated with PD are presented.</abstract><cop>Athens</cop><pub>Spandidos Publications</pub><pmid>34447476</pmid><doi>10.3892/etm.2021.10517</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1792-0981 |
| ispartof | Experimental and therapeutic medicine, 2021-10, Vol.22 (4), Article 1083 |
| issn | 1792-0981 1792-1015 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8355716 |
| source | PubMed Central |
| subjects | Appetite Body mass index Causes of Complications and side effects Constipation Defecation Deglutition disorders Dementia Development and progression Dyskinesia Dysphagia Educational aspects Fecal incontinence Gastrointestinal diseases Helicobacter infections Infections Malnutrition Motility Osteoporosis Parkinson's disease Pathogenesis Patients Pharmacokinetics Pneumonia Quality of life Review Risk factors Vitamin deficiency |
| title | Gastro‑intestinal dysfunctions in Parkinson's disease (Review) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T22%3A19%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastro%E2%80%91intestinal%20dysfunctions%20in%20Parkinson's%20disease%20(Review)&rft.jtitle=Experimental%20and%20therapeutic%20medicine&rft.au=Ivan,%20Irina-Florina&rft.date=2021-10-01&rft.volume=22&rft.issue=4&rft.artnum=1083&rft.issn=1792-0981&rft.eissn=1792-1015&rft_id=info:doi/10.3892/etm.2021.10517&rft_dat=%3Cgale_pubme%3EA676649725%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2568493353&rft_id=info:pmid/34447476&rft_galeid=A676649725&rfr_iscdi=true |