Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

In childhood cancer survivors (CCS) at risk for heart failure, echocardiographic surveillance recommendations are currently based on anthracyclines and chest-directed radiotherapy dose. Whether the ejection fraction (EF) measured at an initial surveillance echocardiogram can refine these recommendat...

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Veröffentlicht in:JACC CardioOncology 2021-03, Vol.3 (1), p.62-72
Hauptverfasser: Leerink, Jan M., van der Pal, Helena J.H., Kremer, Leontien C.M., Feijen, Elizabeth A.M., Meregalli, Paola G., Pourier, Milanthy S., Merkx, Remy, Bellersen, Louise, van Dalen, Elvira C., Loonen, Jacqueline, Pinto, Yigal M., Kapusta, Livia, Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M.
Format: Artikel
Sprache:eng
Schlagworte:
cardio-oncology
childhood cancer survivors
echocardiography
Original Research
risk prediction model
surveillance
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Zusammenfassung:In childhood cancer survivors (CCS) at risk for heart failure, echocardiographic surveillance recommendations are currently based on anthracyclines and chest-directed radiotherapy dose. Whether the ejection fraction (EF) measured at an initial surveillance echocardiogram can refine these recommendations is unknown. The purpose of this study was to assess the added predictive value of EF at >5 years after cancer diagnosis to anthracyclines and chest-directed radiotherapy dose in CCS, for the development of left ventricular dysfunction with an ejection fraction 
ISSN:2666-0873
2666-0873
DOI:10.1016/j.jaccao.2020.11.013