Androgen replacement therapy for cancer‐related symptoms in male: result of prospective randomized trial (ARTFORM study)

Background Hypogonadism associated with cancer is reported to cause cachexia and a variety of physical and psychological symptoms. This study aims to evaluate whether androgen replacement therapy can improve cancer‐related symptoms in male advanced cancer patients. Methods An investigator‐initiated,...

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Veröffentlicht in:	Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2021-08, Vol.12 (4), p.831-842
Hauptverfasser:	Izumi, Kouji, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Nohara, Takahiro, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Nanjo, Shigeki, Yamada, Tadaaki, Ohtsubo, Koshiro, Yano, Seiji, Mizokami, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced cancer Androgen replacement therapy Androgens Anorexia Biomarkers Blood Cachexia Cancer therapies Chemotherapy Creatinine Enzymes General & Internal Medicine Geriatrics & Gerontology Health‐related quality of life Immunoassay Immunotherapy Informed consent Insulin-like growth factors Life Sciences & Biomedicine Male hypogonadism Medicine, General & Internal Metastasis Original Palliative care Patient satisfaction Prostate cancer Quality of life Questionnaires Radiation therapy Science & Technology Software Testosterone
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Zusammenfassung:	Background Hypogonadism associated with cancer is reported to cause cachexia and a variety of physical and psychological symptoms. This study aims to evaluate whether androgen replacement therapy can improve cancer‐related symptoms in male advanced cancer patients. Methods An investigator‐initiated, prospective, and randomized controlled study was conducted. Patients with low serum testosterone levels (total or free testosterone levels were
ISSN:	2190-5991 2190-6009
DOI:	10.1002/jcsm.12716