Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples

The COVID-19 pandemic, which began in 2020 is testing economic resilience and surge capacity of healthcare providers worldwide. At the time of writing, positive detection of the SARS-CoV-2 virus remains the only method for diagnosing COVID-19 infection. Rapid upscaling of national SARS-CoV-2 genome...

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Veröffentlicht in:	Journal of medical microbiology 2021-03, Vol.70 (3)
Hauptverfasser:	Thompson, Jamie L, Downie Ruiz Velasco, Angela, Cardall, Alice, Tarbox, Rebecca, Richardson, Jaineeta, Clarke, Gemma, Lister, Michelle, Howson-Wells, Hannah C, Fleming, Vicki M, Khakh, Manjinder, Sloan, Tim, Duckworth, Nichola, Walsh, Sarah, Denning, Chris, McClure, C Patrick, Benest, Andrew V, Seedhouse, Claire H
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 - diagnosis COVID-19 Nucleic Acid Testing Culture Media Disease, Diagnosis and Diagnostics Hot Temperature Humans Reagent Kits, Diagnostic RNA, Viral - genetics RNA, Viral - isolation & purification SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Sensitivity and Specificity Specimen Handling - methods Virus Inactivation
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Zusammenfassung:	The COVID-19 pandemic, which began in 2020 is testing economic resilience and surge capacity of healthcare providers worldwide. At the time of writing, positive detection of the SARS-CoV-2 virus remains the only method for diagnosing COVID-19 infection. Rapid upscaling of national SARS-CoV-2 genome testing presented challenges: (1) Unpredictable supply chains of reagents and kits for virus inactivation, RNA extraction and PCR-detection of viral genomes. (2) Rapid time to result of
ISSN:	0022-2615 1473-5644
DOI:	10.1099/jmm.0.001301