Molecular docking of potential inhibitors with the mTOR protein

Molecular docking of potential inhibitors with the mTOR protein

The mTOR (mammalian or mechanistic Target of Rapamycin) is linked with oral cancer. Therefore, it is of interest to study the molecular docking-based binding of paclitaxel (a FDA approved drug for oral cancer) and its analogues with mTOR. Hence, we report the binding features of 10-Deacetyltaxol, 7-...

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Veröffentlicht in:Bioinformation 2021-01, Vol.17 (1), p.212-217
Hauptverfasser: Fathima, Jh Shazia, Selvaraj, Jayaraman, Sivabalan, Venkatacalam, Rekha, Umapathy Vidhya, Ponnulakshmi, Rajagopal, Vishnupriya, Veeraraghavan, Kullappan, Malathi, Sreekandan, Radhika Nalinakumari, Mohan, Surapaneni Krishna, Vijayalakshmi, Periyasamy
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Cancer
Molecular docking
Oral cancer
Paclitaxel
Rapamycin
TOR protein
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Beschreibung
Zusammenfassung:The mTOR (mammalian or mechanistic Target of Rapamycin) is linked with oral cancer. Therefore, it is of interest to study the molecular docking-based binding of paclitaxel (a FDA approved drug for oral cancer) and its analogues with mTOR. Hence, we report the binding features of 10-Deacetyltaxol, 7-Epi-10-deacetyltaxol, 7-Epi-Taxol and 6alpha-Hydroxypaclitaxel with mTOR for further consideration.
ISSN:0973-2063
0973-8894
0973-2063
DOI:10.6026/97320630017212