Differences between rural and urban prostate cancer patients
Background We hypothesized that the residency status (rural area [RA] vs urban clusters [UC] vs urban areas [UA]) affects stage and cancer-specific mortality (CSM) in contemporary newly diagnosed prostate cancer (PCa) patients of all stages, regardless of treatment. Methods Newly diagnosed PCa patie...
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| Veröffentlicht in: | World journal of urology 2021-07, Vol.39 (7), p.2507-2514 |
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| creator | Stolzenbach, Lara Franziska Deuker, Marina Collà-Ruvolo, Claudia Nocera, Luigi Tian, Zhe Maurer, Tobias Tilki, Derya Briganti, Alberto Saad, Fred Mirone, Vincenzo Chun, Felix K. H. Graefen, Markus Karakiewicz, Pierre I. |
| description | Background
We hypothesized that the residency status (rural area [RA] vs urban clusters [UC] vs urban areas [UA]) affects stage and cancer-specific mortality (CSM) in contemporary newly diagnosed prostate cancer (PCa) patients of all stages, regardless of treatment.
Methods
Newly diagnosed PCa patients with available residency status were abstracted from the Surveillance, Epidemiology, and End Results database (2004–2016). Propensity-score (PS) matching, cumulative incidence plots, multivariate competing-risks regression (CRR) models were used.
Results
Of 531,468 PCa patients of all stages, 6653 (1.3%) resided in RA, 50,932 (9.6%) in UC and 473,883 (89.2%) in UA. No statistically significant or clinically meaningful differences in stage at presentation or CSM were recorded. Conversely, 10-year other cause-mortality (OCM) rates were 27.2% vs 23.7% vs 18.9% (
p
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| doi_str_mv | 10.1007/s00345-020-03483-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8332582</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2557675453</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-38c2c40e1e0dbe3e138624a93291893f720f4c7d7222e355802fd02686d17ea73</originalsourceid><addsrcrecordid>eNp9kUtrHDEQhEVIiNePP5BDGMjFl3Fa3dJIAyFg1o8EDLkkZ6HV9DhjdjUbacbG_z6y13Eeh5wk6E9VXSoh3kg4kQDmfQYgpWtAqMvFUm1eiIVURLU12LwUCzCoatVa2hP7Od8ASNOAfi32iKTW0NBCfDgb-p4Tx8C5WvF0xxyrNCe_rnzsqjmtfKy2acyTn7gKvnCp2vpp4DjlQ_Gq9-vMR0_ngfh2cf51-am--nL5eXl6VQdl1FSTDRgUsGToVkwsyTaofEvYSttSbxB6FUxnEJFJawvYd4CNbTpp2Bs6EB93utt5teEuFO-yoNumYePTvRv94P6exOG7ux5vnSVCbbEIHD8JpPHHzHlymyEHXq995HHODlUxpVZLWdB3_6A345xiiedQa9MYrTQVCndUKF-TE_fPy0hwD-W4XTmulOMey3EPMd7-GeP5ya82CkA7IJdRvOb02_s_sj8BAk-ZRA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2557675453</pqid></control><display><type>article</type><title>Differences between rural and urban prostate cancer patients</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Stolzenbach, Lara Franziska ; Deuker, Marina ; Collà-Ruvolo, Claudia ; Nocera, Luigi ; Tian, Zhe ; Maurer, Tobias ; Tilki, Derya ; Briganti, Alberto ; Saad, Fred ; Mirone, Vincenzo ; Chun, Felix K. H. ; Graefen, Markus ; Karakiewicz, Pierre I.</creator><creatorcontrib>Stolzenbach, Lara Franziska ; Deuker, Marina ; Collà-Ruvolo, Claudia ; Nocera, Luigi ; Tian, Zhe ; Maurer, Tobias ; Tilki, Derya ; Briganti, Alberto ; Saad, Fred ; Mirone, Vincenzo ; Chun, Felix K. H. ; Graefen, Markus ; Karakiewicz, Pierre I.</creatorcontrib><description>Background
We hypothesized that the residency status (rural area [RA] vs urban clusters [UC] vs urban areas [UA]) affects stage and cancer-specific mortality (CSM) in contemporary newly diagnosed prostate cancer (PCa) patients of all stages, regardless of treatment.
Methods
Newly diagnosed PCa patients with available residency status were abstracted from the Surveillance, Epidemiology, and End Results database (2004–2016). Propensity-score (PS) matching, cumulative incidence plots, multivariate competing-risks regression (CRR) models were used.
Results
Of 531,468 PCa patients of all stages, 6653 (1.3%) resided in RA, 50,932 (9.6%) in UC and 473,883 (89.2%) in UA. No statistically significant or clinically meaningful differences in stage at presentation or CSM were recorded. Conversely, 10-year other cause-mortality (OCM) rates were 27.2% vs 23.7% vs 18.9% (
p
< 0.001) in RA vs UC vs UA patients, respectively. In CRR models, RA (subhazard ratio [SHR] 1.38;
p
< 0.001) and UC (SHR 1.18;
p
< 0.001) were independent predictors for higher OCM relative to UA. These differences remained statistically significant in fully PS-adjusted multivariate CRR models.
Conclusion
RA, and to a lesser extent UC, PCa patients are at higher risk of OCM than UA patients. Higher OCM may indicate shorter life expectancy and should be considered in treatment decision making.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-020-03483-7</identifier><identifier>PMID: 33155063</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Decision making ; Epidemiology ; Humans ; Life span ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Neoplasm Staging ; Nephrology ; Oncology ; Original ; Original Article ; Patients ; Prostate cancer ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Regression analysis ; Retrospective Studies ; Rural Health ; Statistical analysis ; United States - epidemiology ; Urban Health ; Urology</subject><ispartof>World journal of urology, 2021-07, Vol.39 (7), p.2507-2514</ispartof><rights>The Author(s) 2020</rights><rights>2020. The Author(s).</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-38c2c40e1e0dbe3e138624a93291893f720f4c7d7222e355802fd02686d17ea73</citedby><cites>FETCH-LOGICAL-c474t-38c2c40e1e0dbe3e138624a93291893f720f4c7d7222e355802fd02686d17ea73</cites><orcidid>0000-0003-2747-4153</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-020-03483-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-020-03483-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33155063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stolzenbach, Lara Franziska</creatorcontrib><creatorcontrib>Deuker, Marina</creatorcontrib><creatorcontrib>Collà-Ruvolo, Claudia</creatorcontrib><creatorcontrib>Nocera, Luigi</creatorcontrib><creatorcontrib>Tian, Zhe</creatorcontrib><creatorcontrib>Maurer, Tobias</creatorcontrib><creatorcontrib>Tilki, Derya</creatorcontrib><creatorcontrib>Briganti, Alberto</creatorcontrib><creatorcontrib>Saad, Fred</creatorcontrib><creatorcontrib>Mirone, Vincenzo</creatorcontrib><creatorcontrib>Chun, Felix K. H.</creatorcontrib><creatorcontrib>Graefen, Markus</creatorcontrib><creatorcontrib>Karakiewicz, Pierre I.</creatorcontrib><title>Differences between rural and urban prostate cancer patients</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Background
We hypothesized that the residency status (rural area [RA] vs urban clusters [UC] vs urban areas [UA]) affects stage and cancer-specific mortality (CSM) in contemporary newly diagnosed prostate cancer (PCa) patients of all stages, regardless of treatment.
Methods
Newly diagnosed PCa patients with available residency status were abstracted from the Surveillance, Epidemiology, and End Results database (2004–2016). Propensity-score (PS) matching, cumulative incidence plots, multivariate competing-risks regression (CRR) models were used.
Results
Of 531,468 PCa patients of all stages, 6653 (1.3%) resided in RA, 50,932 (9.6%) in UC and 473,883 (89.2%) in UA. No statistically significant or clinically meaningful differences in stage at presentation or CSM were recorded. Conversely, 10-year other cause-mortality (OCM) rates were 27.2% vs 23.7% vs 18.9% (
p
< 0.001) in RA vs UC vs UA patients, respectively. In CRR models, RA (subhazard ratio [SHR] 1.38;
p
< 0.001) and UC (SHR 1.18;
p
< 0.001) were independent predictors for higher OCM relative to UA. These differences remained statistically significant in fully PS-adjusted multivariate CRR models.
Conclusion
RA, and to a lesser extent UC, PCa patients are at higher risk of OCM than UA patients. Higher OCM may indicate shorter life expectancy and should be considered in treatment decision making.</description><subject>Aged</subject><subject>Decision making</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Life span</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Nephrology</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Rural Health</subject><subject>Statistical analysis</subject><subject>United States - epidemiology</subject><subject>Urban Health</subject><subject>Urology</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtrHDEQhEVIiNePP5BDGMjFl3Fa3dJIAyFg1o8EDLkkZ6HV9DhjdjUbacbG_z6y13Eeh5wk6E9VXSoh3kg4kQDmfQYgpWtAqMvFUm1eiIVURLU12LwUCzCoatVa2hP7Od8ASNOAfi32iKTW0NBCfDgb-p4Tx8C5WvF0xxyrNCe_rnzsqjmtfKy2acyTn7gKvnCp2vpp4DjlQ_Gq9-vMR0_ngfh2cf51-am--nL5eXl6VQdl1FSTDRgUsGToVkwsyTaofEvYSttSbxB6FUxnEJFJawvYd4CNbTpp2Bs6EB93utt5teEuFO-yoNumYePTvRv94P6exOG7ux5vnSVCbbEIHD8JpPHHzHlymyEHXq995HHODlUxpVZLWdB3_6A345xiiedQa9MYrTQVCndUKF-TE_fPy0hwD-W4XTmulOMey3EPMd7-GeP5ya82CkA7IJdRvOb02_s_sj8BAk-ZRA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Stolzenbach, Lara Franziska</creator><creator>Deuker, Marina</creator><creator>Collà-Ruvolo, Claudia</creator><creator>Nocera, Luigi</creator><creator>Tian, Zhe</creator><creator>Maurer, Tobias</creator><creator>Tilki, Derya</creator><creator>Briganti, Alberto</creator><creator>Saad, Fred</creator><creator>Mirone, Vincenzo</creator><creator>Chun, Felix K. H.</creator><creator>Graefen, Markus</creator><creator>Karakiewicz, Pierre I.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2747-4153</orcidid></search><sort><creationdate>20210701</creationdate><title>Differences between rural and urban prostate cancer patients</title><author>Stolzenbach, Lara Franziska ; Deuker, Marina ; Collà-Ruvolo, Claudia ; Nocera, Luigi ; Tian, Zhe ; Maurer, Tobias ; Tilki, Derya ; Briganti, Alberto ; Saad, Fred ; Mirone, Vincenzo ; Chun, Felix K. H. ; Graefen, Markus ; Karakiewicz, Pierre I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-38c2c40e1e0dbe3e138624a93291893f720f4c7d7222e355802fd02686d17ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Decision making</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Life span</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Staging</topic><topic>Nephrology</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Rural Health</topic><topic>Statistical analysis</topic><topic>United States - epidemiology</topic><topic>Urban Health</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stolzenbach, Lara Franziska</creatorcontrib><creatorcontrib>Deuker, Marina</creatorcontrib><creatorcontrib>Collà-Ruvolo, Claudia</creatorcontrib><creatorcontrib>Nocera, Luigi</creatorcontrib><creatorcontrib>Tian, Zhe</creatorcontrib><creatorcontrib>Maurer, Tobias</creatorcontrib><creatorcontrib>Tilki, Derya</creatorcontrib><creatorcontrib>Briganti, Alberto</creatorcontrib><creatorcontrib>Saad, Fred</creatorcontrib><creatorcontrib>Mirone, Vincenzo</creatorcontrib><creatorcontrib>Chun, Felix K. H.</creatorcontrib><creatorcontrib>Graefen, Markus</creatorcontrib><creatorcontrib>Karakiewicz, Pierre I.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stolzenbach, Lara Franziska</au><au>Deuker, Marina</au><au>Collà-Ruvolo, Claudia</au><au>Nocera, Luigi</au><au>Tian, Zhe</au><au>Maurer, Tobias</au><au>Tilki, Derya</au><au>Briganti, Alberto</au><au>Saad, Fred</au><au>Mirone, Vincenzo</au><au>Chun, Felix K. H.</au><au>Graefen, Markus</au><au>Karakiewicz, Pierre I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences between rural and urban prostate cancer patients</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>39</volume><issue>7</issue><spage>2507</spage><epage>2514</epage><pages>2507-2514</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Background
We hypothesized that the residency status (rural area [RA] vs urban clusters [UC] vs urban areas [UA]) affects stage and cancer-specific mortality (CSM) in contemporary newly diagnosed prostate cancer (PCa) patients of all stages, regardless of treatment.
Methods
Newly diagnosed PCa patients with available residency status were abstracted from the Surveillance, Epidemiology, and End Results database (2004–2016). Propensity-score (PS) matching, cumulative incidence plots, multivariate competing-risks regression (CRR) models were used.
Results
Of 531,468 PCa patients of all stages, 6653 (1.3%) resided in RA, 50,932 (9.6%) in UC and 473,883 (89.2%) in UA. No statistically significant or clinically meaningful differences in stage at presentation or CSM were recorded. Conversely, 10-year other cause-mortality (OCM) rates were 27.2% vs 23.7% vs 18.9% (
p
< 0.001) in RA vs UC vs UA patients, respectively. In CRR models, RA (subhazard ratio [SHR] 1.38;
p
< 0.001) and UC (SHR 1.18;
p
< 0.001) were independent predictors for higher OCM relative to UA. These differences remained statistically significant in fully PS-adjusted multivariate CRR models.
Conclusion
RA, and to a lesser extent UC, PCa patients are at higher risk of OCM than UA patients. Higher OCM may indicate shorter life expectancy and should be considered in treatment decision making.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33155063</pmid><doi>10.1007/s00345-020-03483-7</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2747-4153</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Decision making Epidemiology Humans Life span Male Medicine Medicine & Public Health Middle Aged Mortality Neoplasm Staging Nephrology Oncology Original Original Article Patients Prostate cancer Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Regression analysis Retrospective Studies Rural Health Statistical analysis United States - epidemiology Urban Health Urology |
| title | Differences between rural and urban prostate cancer patients |
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