Myopathic Cardiac Genotypes Increase Risk for Myocarditis
Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac ge...
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Veröffentlicht in: | JACC. Basic to translational science 2021-07, Vol.6 (7), p.584-592 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the extent of this association, we performed genomic sequencing in predominantly adult patients with acute myocarditis and matched control subjects. Putatively deleterious variants in a broad set of cardiac genes were found in 19 of 117 acute myocarditis cases vs 34 of 468 control subjects
0.003). Thirteen genes classically associated with cardiomyopathy or neuromuscular disorders with cardiac involvement were implicated, including >1 associated damaging variant in
,
and
. Phenotypes of subjects who have acute myocarditis with or without deleterious variants were similar, indicating that genetic testing is necessary to differentiate them. |
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ISSN: | 2452-302X 2452-302X |
DOI: | 10.1016/j.jacbts.2021.06.001 |