Elevated liver enzymes in hospitalized patients with COVID-19 in Singapore

Liver dysfunction in patients with COVID-19 (coronavirus disease 2019) has been described. However, it is not clear if the presence of abnormal liver function tests at presentation was related to underlying undiagnosed liver disease, or a result of the viral infection.We retrospectively examined the...

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Veröffentlicht in:	Medicine (Baltimore) 2021-07, Vol.100 (30), p.e26719-e26719
Hauptverfasser:	Ngiam, Jinghao Nicholas, Chew, Nicholas, Tham, Sai Meng, Lim, Zhen Yu, Li, Tony Yi-Wei, Cen, Shuyun, Tambyah, Paul Anantharajah, Santosa, Amelia, Muthiah, Mark, Sia, Ching-Hui, Cross, Gail Brenda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aspartate Aminotransferases - blood COVID-19 - blood COVID-19 - complications Female Ferritins - blood Humans L-Lactate Dehydrogenase - blood Leukocyte Count Liver Diseases - blood Liver Diseases - etiology Liver Function Tests Male Middle Aged Observational Study Retrospective Studies Risk Factors Singapore
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Zusammenfassung:	Liver dysfunction in patients with COVID-19 (coronavirus disease 2019) has been described. However, it is not clear if the presence of abnormal liver function tests at presentation was related to underlying undiagnosed liver disease, or a result of the viral infection.We retrospectively examined the first 554 consecutive polymerase chain reaction positive SARS-CoV-2 patients admitted from February 2020 to April 2020 to our academic medical centre. We reviewed their clinical data, chest radiography and laboratory studies obtained within 24 hour of admission.Despite similar hemodynamic parameters, we found significant aspartate transaminase elevation (64 ± 141 vs 35 ± 23 U/L, P
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000026719