Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott Architect(TM) SARS-CoV-2 IgG assay indicated that the assays had high concordan...

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Veröffentlicht in:	PloS one 2021-07, Vol.16 (7), p.e0255208-e0255208, Article 0255208
Hauptverfasser:	Wadhwa, Ashutosh, Yin, Sherry, Freeman, Brandi, Hershow, Rebecca B., Killerby, Marie, Yousaf, Anna R., Lester, Sandra, Mills, Lisa, Buono, Sean A., Pomeroy, Mary, Owusu, Daniel, Chu, Victoria T., Tate, Jacqueline E., Bhattacharyya, Sanjib, Hall, Patricia, Thornburg, Natalie J., Kirking, Hannah L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies Antigens Architects Assaying Biology and life sciences Comparative analysis Coronaviruses COVID-19 diagnostic tests COVID-19 vaccines Disease transmission Enrollments Enzyme-linked immunosorbent assay Households Immunization Immunoassay Immunoglobulin G Medical laboratories Medicine and Health Sciences Multidisciplinary Sciences Nucleocapsids Proteins Public health Research and Analysis Methods Science & Technology Science & Technology - Other Topics Serology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Supervision Viral antibodies
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Beschreibung
Zusammenfassung:	Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott Architect(TM) SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0255208