Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients

Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients

•Elevated IL-6 may play an important role in the pathophysiology of COVID-19 yet attenuated response is not seen across all severe patients.•This study reports significantly elevated IL-6 in COVID-19 infected hospitalized patients, n = 100 (p-value 

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Bibliographische Detailangaben
Veröffentlicht in:Cytokine (Philadelphia, Pa.) Pa.), 2021-12, Vol.148, p.155662-155662, Article 155662
Hauptverfasser: Smieszek, Sandra P., Przychodzen, Bartlomiej P., Polymeropoulos, Vasilios M., Polymeropoulos, Christos M., Polymeropoulos, Mihael H.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
COVID-19 - blood
COVID-19 - genetics
COVID-19 - mortality
Heterozygote
Humans
Interleukin-6 - blood
Interleukin-6 - genetics
Polymorphism, Single Nucleotide - genetics
Receptors, Interleukin-6 - genetics
Short Communication
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Beschreibung
Zusammenfassung:•Elevated IL-6 may play an important role in the pathophysiology of COVID-19 yet attenuated response is not seen across all severe patients.•This study reports significantly elevated IL-6 in COVID-19 infected hospitalized patients, n = 100 (p-value 
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2021.155662