A genome-wide library of MADM mice for single-cell genetic mosaic analysis

Mosaic analysis with double markers (MADM) offers one approach to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM applications include the analysis of lineage, single-cell morphology and physiology, genomic imprinting phenotypes, and dissect...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-06, Vol.35 (12), p.109274-109274, Article 109274
Hauptverfasser:	Contreras, Ximena, Amberg, Nicole, Davaatseren, Amarbayasgalan, Hansen, Andi H., Sonntag, Johanna, Andersen, Lill, Bernthaler, Tina, Streicher, Carmen, Heger, Anna, Johnson, Randy L., Schwarz, Lindsay A., Luo, Liqun, Rülicke, Thomas, Hippenmeyer, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli - metabolism Adult Stem Cells - metabolism Animals Chromatids - genetics Chromosome Segregation Chromosomes, Mammalian - genetics Disease Models, Animal functional gene analysis Gene Library Genetic Markers genetic mosaic Genome Genomic Imprinting lineage Liver - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitosis Models, Biological Mosaic Analysis with Double Markers (MADM) Mosaicism Neoplasms - genetics Neoplasms - pathology Phenotype Recombination, Genetic - genetics single cell Single-Cell Analysis sister chromatid Segregation Pattern stem cell Stem Cell Niche Uniparental Disomy
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