Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients

Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-07, Vol.65 (8), p.e0029021
Hauptverfasser:	Arrieta, Antonio C, Neely, Michael, Day, J Christopher, Rheingold, Susan R, Sue, Paul K, Muller, William J, Danziger-Isakov, Lara A, Chu, Julie, Yildirim, Inci, McComsey, Grace A, Frangoul, Haydar A, Chen, Tempe K, Statler, Victoria A, Steinbach, William J, Yin, Dwight E, Hamed, Kamal, Jones, Mark E, Lademacher, Christopher, Desai, Amit, Micklus, Kelley, Phillips, Desiree Leiva, Kovanda, Laura L, Walsh, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Child Child, Preschool Clinical Therapeutics Humans Infant Invasive Fungal Infections - drug therapy Nitriles - therapeutic use Pyridines - adverse effects Triazoles - therapeutic use
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Zusammenfassung:	Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified by age (1 to
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00290-21