A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole

A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole

We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H ) could be detected and quantified with good...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2021-07, Vol.65 (8), p.e0245820-e0245820
Hauptverfasser: Falces-Romero, Iker, Mingorance, Jesús, García-Rodríguez, Julio, Cendejas-Bueno, Emilio
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Procedures
Drug Monitoring
Humans
Reproducibility of Results
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Voriconazole
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Zusammenfassung:We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H ) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02458-20