Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women
BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in...
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| Veröffentlicht in: | Medical science monitor 2021-07, Vol.27, p.e929100-e929100 |
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| creator | Chen, Yingying Dong, Jie Chu, Boliang Zhang, Xiaoxing Ru, Xiaofang Chen, Yun Chen, Yunyan Cheng, Xiaodong |
| description | BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in pregnant women. MATERIAL AND METHODS A total of 1774 pregnant women were included, and 1774 non-pregnant women were selected as controls. Cervical exfoliated cells were collected from all women for HR-HPV (AptimaE6, E7mRNA) and ThinPrep cytologic testing, and the vaginal discharge of all pregnant women was tested for pH level and routine pathogenic microorganisms. RESULTS The HPV-16-positive and HPV-16/18/45-positive rates in pregnant women were higher than those of non-pregnant women (P |
| doi_str_mv | 10.12659/MSM.929100 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8284082</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2550630913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-e7498d38140bd167dda848ee11f92744d6a44ccef9438e9ac6a11de6cf5e90163</originalsourceid><addsrcrecordid>eNpVkU1LJDEQhoPs4vfJu-S4sLQmnXQmuQgyqCMou-guHkOZVM9ktzsZk25h__02joqequB9eKvgIeSIsxNeq8ac3t7fnpjacMa2yC5XUlRi1rAvH_YdslfKH8ZqrVizTXaErKXmQu8SmK8ggxswhzIEVyhET--wgwE9vZyClAtNLV2E5aq6C-UvXYw9RPoT1qHrUg_PIY-FXscW3RBSpGHKMi4jxIE-pB7jAfnaQlfw8HXuk9-XF7_mi-rmx9X1_PymckLzocKZNNpPq2SPnquZ96ClRuS8NfVMSq9ASuewNVJoNOAUcO5RubZBw7gS--Rs07seH3v0DuOQobPrHHrI_2yCYD8nMazsMj1bXWvJdD0VfHstyOlpxDLYPhSHXQcR01hs3TRMCWa4mNDvG9TlVErG9v0MZ_ZFip2k2I2UiT7--Nk7-2ZB_AcKHok9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2550630913</pqid></control><display><type>article</type><title>Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Chen, Yingying ; Dong, Jie ; Chu, Boliang ; Zhang, Xiaoxing ; Ru, Xiaofang ; Chen, Yun ; Chen, Yunyan ; Cheng, Xiaodong</creator><creatorcontrib>Chen, Yingying ; Dong, Jie ; Chu, Boliang ; Zhang, Xiaoxing ; Ru, Xiaofang ; Chen, Yun ; Chen, Yunyan ; Cheng, Xiaodong</creatorcontrib><description>BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in pregnant women. MATERIAL AND METHODS A total of 1774 pregnant women were included, and 1774 non-pregnant women were selected as controls. Cervical exfoliated cells were collected from all women for HR-HPV (AptimaE6, E7mRNA) and ThinPrep cytologic testing, and the vaginal discharge of all pregnant women was tested for pH level and routine pathogenic microorganisms. RESULTS The HPV-16-positive and HPV-16/18/45-positive rates in pregnant women were higher than those of non-pregnant women (P<0.05). There was a statistically significant difference in HR-HPV-positive rate, HPV-16-positive rate, and non-HPV-16/18/45-positive rate among pregnant women of different ages (P<0.05). There was a statistically significant difference in HR-HPV-positive rate and non-HPV-16/18/45-positive rate in the first, second, and third trimester (P<0.05). The HR-HPV-positive rate, HPV-16-positive rate, HPV-18/45-positive rate, and non-HPV-16/18/45-positive rate of pregnant women with concurrent infection were higher than those in women without concurrent infection (P<0.05). The HR-HPV-positive and HPV-16/18/45-positive rates in pregnant women were associated with cytologic examination results (P<0.05). CONCLUSIONS The overall infection rates of HR-HPV-16 and HR-HPV-18/45 in pregnant women were higher than those in non-pregnant women. The gestation period was found to be a susceptible period for infection with HR-HPV, and we recommend the implementation of cervical cancer screening based on HR-HPV testing in pregnant women.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.929100</identifier><identifier>PMID: 34248138</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Clinical Research ; Early Detection of Cancer ; Female ; Human papillomavirus 16 ; Humans ; Middle Aged ; Papillomavirus Infections - epidemiology ; Pregnancy ; Pregnant Women ; Uterine Cervical Neoplasms</subject><ispartof>Medical science monitor, 2021-07, Vol.27, p.e929100-e929100</ispartof><rights>Med Sci Monit, 2021 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-e7498d38140bd167dda848ee11f92744d6a44ccef9438e9ac6a11de6cf5e90163</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284082/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284082/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34248138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yingying</creatorcontrib><creatorcontrib>Dong, Jie</creatorcontrib><creatorcontrib>Chu, Boliang</creatorcontrib><creatorcontrib>Zhang, Xiaoxing</creatorcontrib><creatorcontrib>Ru, Xiaofang</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Chen, Yunyan</creatorcontrib><creatorcontrib>Cheng, Xiaodong</creatorcontrib><title>Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in pregnant women. MATERIAL AND METHODS A total of 1774 pregnant women were included, and 1774 non-pregnant women were selected as controls. Cervical exfoliated cells were collected from all women for HR-HPV (AptimaE6, E7mRNA) and ThinPrep cytologic testing, and the vaginal discharge of all pregnant women was tested for pH level and routine pathogenic microorganisms. RESULTS The HPV-16-positive and HPV-16/18/45-positive rates in pregnant women were higher than those of non-pregnant women (P<0.05). There was a statistically significant difference in HR-HPV-positive rate, HPV-16-positive rate, and non-HPV-16/18/45-positive rate among pregnant women of different ages (P<0.05). There was a statistically significant difference in HR-HPV-positive rate and non-HPV-16/18/45-positive rate in the first, second, and third trimester (P<0.05). The HR-HPV-positive rate, HPV-16-positive rate, HPV-18/45-positive rate, and non-HPV-16/18/45-positive rate of pregnant women with concurrent infection were higher than those in women without concurrent infection (P<0.05). The HR-HPV-positive and HPV-16/18/45-positive rates in pregnant women were associated with cytologic examination results (P<0.05). CONCLUSIONS The overall infection rates of HR-HPV-16 and HR-HPV-18/45 in pregnant women were higher than those in non-pregnant women. The gestation period was found to be a susceptible period for infection with HR-HPV, and we recommend the implementation of cervical cancer screening based on HR-HPV testing in pregnant women.</description><subject>Adult</subject><subject>Clinical Research</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Human papillomavirus 16</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Pregnancy</subject><subject>Pregnant Women</subject><subject>Uterine Cervical Neoplasms</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LJDEQhoPs4vfJu-S4sLQmnXQmuQgyqCMou-guHkOZVM9ktzsZk25h__02joqequB9eKvgIeSIsxNeq8ac3t7fnpjacMa2yC5XUlRi1rAvH_YdslfKH8ZqrVizTXaErKXmQu8SmK8ggxswhzIEVyhET--wgwE9vZyClAtNLV2E5aq6C-UvXYw9RPoT1qHrUg_PIY-FXscW3RBSpGHKMi4jxIE-pB7jAfnaQlfw8HXuk9-XF7_mi-rmx9X1_PymckLzocKZNNpPq2SPnquZ96ClRuS8NfVMSq9ASuewNVJoNOAUcO5RubZBw7gS--Rs07seH3v0DuOQobPrHHrI_2yCYD8nMazsMj1bXWvJdD0VfHstyOlpxDLYPhSHXQcR01hs3TRMCWa4mNDvG9TlVErG9v0MZ_ZFip2k2I2UiT7--Nk7-2ZB_AcKHok9</recordid><startdate>20210712</startdate><enddate>20210712</enddate><creator>Chen, Yingying</creator><creator>Dong, Jie</creator><creator>Chu, Boliang</creator><creator>Zhang, Xiaoxing</creator><creator>Ru, Xiaofang</creator><creator>Chen, Yun</creator><creator>Chen, Yunyan</creator><creator>Cheng, Xiaodong</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210712</creationdate><title>Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women</title><author>Chen, Yingying ; Dong, Jie ; Chu, Boliang ; Zhang, Xiaoxing ; Ru, Xiaofang ; Chen, Yun ; Chen, Yunyan ; Cheng, Xiaodong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-e7498d38140bd167dda848ee11f92744d6a44ccef9438e9ac6a11de6cf5e90163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Clinical Research</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Human papillomavirus 16</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Pregnancy</topic><topic>Pregnant Women</topic><topic>Uterine Cervical Neoplasms</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yingying</creatorcontrib><creatorcontrib>Dong, Jie</creatorcontrib><creatorcontrib>Chu, Boliang</creatorcontrib><creatorcontrib>Zhang, Xiaoxing</creatorcontrib><creatorcontrib>Ru, Xiaofang</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Chen, Yunyan</creatorcontrib><creatorcontrib>Cheng, Xiaodong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yingying</au><au>Dong, Jie</au><au>Chu, Boliang</au><au>Zhang, Xiaoxing</au><au>Ru, Xiaofang</au><au>Chen, Yun</au><au>Chen, Yunyan</au><au>Cheng, Xiaodong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2021-07-12</date><risdate>2021</risdate><volume>27</volume><spage>e929100</spage><epage>e929100</epage><pages>e929100-e929100</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND Cervical cancer is a risk for women worldwide. The aim of this study was to examine the occurrence of high-risk human papillomavirus (HR-HPV) infection and its related factors in pregnant women and provide a scientific basis for the targeted prevention and treatment of cervical cancer in pregnant women. MATERIAL AND METHODS A total of 1774 pregnant women were included, and 1774 non-pregnant women were selected as controls. Cervical exfoliated cells were collected from all women for HR-HPV (AptimaE6, E7mRNA) and ThinPrep cytologic testing, and the vaginal discharge of all pregnant women was tested for pH level and routine pathogenic microorganisms. RESULTS The HPV-16-positive and HPV-16/18/45-positive rates in pregnant women were higher than those of non-pregnant women (P<0.05). There was a statistically significant difference in HR-HPV-positive rate, HPV-16-positive rate, and non-HPV-16/18/45-positive rate among pregnant women of different ages (P<0.05). There was a statistically significant difference in HR-HPV-positive rate and non-HPV-16/18/45-positive rate in the first, second, and third trimester (P<0.05). The HR-HPV-positive rate, HPV-16-positive rate, HPV-18/45-positive rate, and non-HPV-16/18/45-positive rate of pregnant women with concurrent infection were higher than those in women without concurrent infection (P<0.05). The HR-HPV-positive and HPV-16/18/45-positive rates in pregnant women were associated with cytologic examination results (P<0.05). CONCLUSIONS The overall infection rates of HR-HPV-16 and HR-HPV-18/45 in pregnant women were higher than those in non-pregnant women. The gestation period was found to be a susceptible period for infection with HR-HPV, and we recommend the implementation of cervical cancer screening based on HR-HPV testing in pregnant women.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>34248138</pmid><doi>10.12659/MSM.929100</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Clinical Research Early Detection of Cancer Female Human papillomavirus 16 Humans Middle Aged Papillomavirus Infections - epidemiology Pregnancy Pregnant Women Uterine Cervical Neoplasms |
| title | Characteristics and Related Factors of High-Risk Human Papillomavirus Infection in Pregnant Women |
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