Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic variatio...

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Veröffentlicht in:	Human molecular genetics 2021-07, Vol.30 (15), p.1443-1456
Hauptverfasser:	Palmer, Nicholette D, Kahali, Bratati, Kuppa, Annapurna, Chen, Yanhua, Du, Xiaomeng, Feitosa, Mary F, Bielak, Lawrence F, O'Connell, Jeffrey R, Musani, Solomon K, Guo, Xiuqing, Smith, Albert V, Ryan, Kathleen A, Eirksdottir, Gudny, Allison, Matthew A, Bowden, Donald W, Budoff, Matthew J, Carr, J Jeffrey, Chen, Yii-Der I, Taylor, Kent D, Correa, Adolfo, Crudup, Breland F, Halligan, Brian, Yang, Jian, Kardia, Sharon L R, Launer, Lenore J, Fu, Yi-Ping, Mosley, Thomas H, Norris, Jill M, Terry, James G, O'Donnell, Christopher J, Rotter, Jerome I, Wagenknecht, Lynne E, Gudnason, Vilmundur, Province, Michael A, Peyser, Patricia A, Speliotes, Elizabeth K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase Alleles Alzheimer Disease - genetics Apolipoproteins E - genetics Apolipoproteins E - metabolism Association Studies Databases, Genetic Exome - genetics Gene Frequency - genetics Genome-Wide Association Study - methods Humans Liver Liver Cirrhosis - genetics Myocardial Infarction - genetics Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Obesity - genetics Obesity - metabolism Phenotype Polymorphism, Single Nucleotide - genetics Prognosis Risk Factors Triglycerides
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Zusammenfassung:	Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic variation associated with NAFLD and correlated metabolic traits and diseases. An exome array meta-analysis was carried out among eight multiethnic population-based cohorts (n = 16 492) with computed tomography (CT) measured hepatic steatosis. A fixed effects meta-analysis identified five exome-wide significant loci (P
ISSN:	0964-6906 1460-2083 1460-2083
DOI:	10.1093/hmg/ddab096