Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis

In this phase 3 trial for the treatment of tuberculosis, a 4-month rifapentine-based regimen containing moxifloxacin was noninferior to a standard 6-month regimen.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-05, Vol.384 (18), p.1705-1718
Hauptverfasser:	Dorman, Susan E, Nahid, Payam, Kurbatova, Ekaterina V, Phillips, Patrick P.J, Bryant, Kia, Dooley, Kelly E, Engle, Melissa, Goldberg, Stefan V, Phan, Ha T.T, Hakim, James, Johnson, John L, Lourens, Madeleine, Martinson, Neil A, Muzanyi, Grace, Narunsky, Kim, Nerette, Sandy, Nguyen, Nhung V, Pham, Thuong H, Pierre, Samuel, Purfield, Anne E, Samaneka, Wadzanai, Savic, Radojka M, Sanne, Ian, Scott, Nigel A, Shenje, Justin, Sizemore, Erin, Vernon, Andrew, Waja, Ziyaad, Weiner, Marc, Swindells, Susan, Chaisson, Richard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult Adverse events AIDS Antibiotics Antibiotics, Antitubercular - administration & dosage Antibiotics, Antitubercular - adverse effects Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Cavitation Child Clinical trials Confidence Intervals Consortia Drug Administration Schedule Drug dosages Drug Therapy, Combination Ethambutol Female Fluoroquinolones Genomes HIV Human immunodeficiency virus Humans Isoniazid Laboratories Male Microscopy Moxifloxacin Moxifloxacin - administration & dosage Moxifloxacin - adverse effects Mycobacterium tuberculosis - isolation & purification Pyrazinamide Radiography Rifampin Rifampin - administration & dosage Rifampin - adverse effects Sensitivity analysis Tuberculosis Tuberculosis, Pulmonary - drug therapy Young Adult
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Beschreibung
Zusammenfassung:	In this phase 3 trial for the treatment of tuberculosis, a 4-month rifapentine-based regimen containing moxifloxacin was noninferior to a standard 6-month regimen.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2033400