Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysf...

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Veröffentlicht in:	Microvascular research 2021-11, Vol.138, p.104224-104224, Article 104224
Hauptverfasser:	Andrianto, Al-Farabi, Makhyan Jibril, Nugraha, Ricardo Adrian, Marsudi, Bagas Adhimurda, Azmi, Yusuf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - blood COVID-19 COVID-19 - blood COVID-19 - diagnosis COVID-19 - physiopathology COVID-19 - therapy Endothelial dysfunction Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Female Humans Male Middle Aged Plasminogen Activator Inhibitor 1 - blood Plasminogen activator inhibitor-1 Predictive Value of Tests Prognosis Thrombomodulin Thrombomodulin - blood Tissue Plasminogen Activator - blood Tissue-type plasminogen activator von Willebrand Factor von Willebrand Factor - analysis
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Zusammenfassung:	Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19. A literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients. A total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37–321.48], p
ISSN:	0026-2862 1095-9319
DOI:	10.1016/j.mvr.2021.104224