SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases

SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases

This study aimed to investigate the clinicopathological significance of sine oculis homeobox homolog 1 (SIX1) and eyes absent 1 (EYA1) in patients with chronic hepatitis B (CHB) and other liver diseases. SIX1 and EYA1 levels were detected in human serum and liver tissues by enzyme linked immunosorbe...

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Veröffentlicht in:Annals of translational medicine 2021-06, Vol.9 (12), p.992-992
Hauptverfasser: Xu, Baoyan, Yang, Qiao, Tang, Yingzi, Tan, Zhaoxia, Fu, Haiyan, Peng, Jing, Xiang, Xiaomei, Gan, Linlin, Deng, Guohong, Mao, Qing, Xu, Pin-Xian, Jiang, Yi, Ding, Jianqiang
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Sprache:eng
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Zusammenfassung:This study aimed to investigate the clinicopathological significance of sine oculis homeobox homolog 1 (SIX1) and eyes absent 1 (EYA1) in patients with chronic hepatitis B (CHB) and other liver diseases. SIX1 and EYA1 levels were detected in human serum and liver tissues by enzyme linked immunosorbent assay (ELISA) and immunofluorescent staining method, respectively. The serum SIX1 and EYA1 levels in 313 CHB patients were 7.24±0.11 and 25.21±0.51 ng/mL, respectively, and these values were significantly higher than those in 33 healthy controls (2.84±0.15 and 13.11±1.01 ng/mL, respectively; P
ISSN:2305-5839
2305-5839
DOI:10.21037/atm-21-2526