Analysis of perinatal coagulation function in preeclampsia
To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE).The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were inv...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-07, Vol.100 (26), p.e26482-e26482 |
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| creator | Xu, Chang Li, YunHui Zhang, Wen Wang, QiuShi |
| description | To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE).The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed.Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P |
| doi_str_mv | 10.1097/MD.0000000000026482 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8257867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2546978382</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4502-35268fd96a4811571338837fbd8b0836400de167136c78a4731e6442f11586d13</originalsourceid><addsrcrecordid>eNpdkMtOwzAURC0EoqXwBUgoSzYpftthgVTxllqxgbXlJk5rcONgJ1T9e0JbysMbW-Mzc68GgFMEhwhm4mJyM4Q_B3Mq8R7oI0Z4yjJO90G_U1kqMkF74CjGVwgREZgegh6hKINIkD64HFXaraKNiS-T2gRb6Ua7JPd61jrdWF8lZVvl64etkjoYkzu9qKPVx-Cg1C6ak-09AC93t8_XD-n46f7xejROc8ogTgnDXJZFxjWVCDGBCJGSiHJayCmUhFMIC4N4p_NcSE0FQYZTissOlrxAZACuNrl1O12YIjdVE7RTdbALHVbKa6v-_lR2rmb-Q0nMhOSiCzjfBgT_3prYqIWNuXFOV8a3UWFGeSYkkbhDyQbNg48xmHI3BkH11bqa3Kj_rXeus98b7jzfNXcA3QBL7xoT4ptrlyaoudGuma_zmMhwiiFGUEAM004hmHwCtfuLiA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2546978382</pqid></control><display><type>article</type><title>Analysis of perinatal coagulation function in preeclampsia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Xu, Chang ; Li, YunHui ; Zhang, Wen ; Wang, QiuShi</creator><creatorcontrib>Xu, Chang ; Li, YunHui ; Zhang, Wen ; Wang, QiuShi</creatorcontrib><description>To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE).The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed.Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P < .05). APTT and FIB in PE patients were lower in the day 1 postpartum group than in the prenatal and postpartum day 3 groups, and TT, DD, and fibrin degradation products (FDP) were higher (P < .05). PCT and MPV were highest in the prenatal group (P < .05).Compared with that of healthy pregnant women, the coagulation function of PE patients is in a relatively low-coagulation and high-fibrinolysis state on postpartum day 1, which increases the risk of postpartum hemorrhage and other adverse outcomes.</description><identifier>ISSN: 0025-7974</identifier><identifier>ISSN: 1536-5964</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000026482</identifier><identifier>PMID: 34190173</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Blood Coagulation - physiology ; Blood Coagulation Tests - methods ; China - epidemiology ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinolysis - physiology ; Humans ; Observational Study ; Perinatal Care - methods ; Perinatal Care - statistics & numerical data ; Platelet Count - methods ; Platelet Function Tests - methods ; Postpartum Hemorrhage - blood ; Postpartum Hemorrhage - etiology ; Postpartum Hemorrhage - therapy ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pre-Eclampsia - physiopathology ; Pregnancy ; Pregnancy Outcome - epidemiology</subject><ispartof>Medicine (Baltimore), 2021-07, Vol.100 (26), p.e26482-e26482</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4502-35268fd96a4811571338837fbd8b0836400de167136c78a4731e6442f11586d13</citedby><cites>FETCH-LOGICAL-c4502-35268fd96a4811571338837fbd8b0836400de167136c78a4731e6442f11586d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34190173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Chang</creatorcontrib><creatorcontrib>Li, YunHui</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Wang, QiuShi</creatorcontrib><title>Analysis of perinatal coagulation function in preeclampsia</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE).The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed.Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P < .05). APTT and FIB in PE patients were lower in the day 1 postpartum group than in the prenatal and postpartum day 3 groups, and TT, DD, and fibrin degradation products (FDP) were higher (P < .05). PCT and MPV were highest in the prenatal group (P < .05).Compared with that of healthy pregnant women, the coagulation function of PE patients is in a relatively low-coagulation and high-fibrinolysis state on postpartum day 1, which increases the risk of postpartum hemorrhage and other adverse outcomes.</description><subject>Adult</subject><subject>Blood Coagulation - physiology</subject><subject>Blood Coagulation Tests - methods</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinolysis - physiology</subject><subject>Humans</subject><subject>Observational Study</subject><subject>Perinatal Care - methods</subject><subject>Perinatal Care - statistics & numerical data</subject><subject>Platelet Count - methods</subject><subject>Platelet Function Tests - methods</subject><subject>Postpartum Hemorrhage - blood</subject><subject>Postpartum Hemorrhage - etiology</subject><subject>Postpartum Hemorrhage - therapy</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><issn>0025-7974</issn><issn>1536-5964</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtOwzAURC0EoqXwBUgoSzYpftthgVTxllqxgbXlJk5rcONgJ1T9e0JbysMbW-Mzc68GgFMEhwhm4mJyM4Q_B3Mq8R7oI0Z4yjJO90G_U1kqMkF74CjGVwgREZgegh6hKINIkD64HFXaraKNiS-T2gRb6Ua7JPd61jrdWF8lZVvl64etkjoYkzu9qKPVx-Cg1C6ak-09AC93t8_XD-n46f7xejROc8ogTgnDXJZFxjWVCDGBCJGSiHJayCmUhFMIC4N4p_NcSE0FQYZTissOlrxAZACuNrl1O12YIjdVE7RTdbALHVbKa6v-_lR2rmb-Q0nMhOSiCzjfBgT_3prYqIWNuXFOV8a3UWFGeSYkkbhDyQbNg48xmHI3BkH11bqa3Kj_rXeus98b7jzfNXcA3QBL7xoT4ptrlyaoudGuma_zmMhwiiFGUEAM004hmHwCtfuLiA</recordid><startdate>20210702</startdate><enddate>20210702</enddate><creator>Xu, Chang</creator><creator>Li, YunHui</creator><creator>Zhang, Wen</creator><creator>Wang, QiuShi</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210702</creationdate><title>Analysis of perinatal coagulation function in preeclampsia</title><author>Xu, Chang ; Li, YunHui ; Zhang, Wen ; Wang, QiuShi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4502-35268fd96a4811571338837fbd8b0836400de167136c78a4731e6442f11586d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Blood Coagulation - physiology</topic><topic>Blood Coagulation Tests - methods</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinolysis - physiology</topic><topic>Humans</topic><topic>Observational Study</topic><topic>Perinatal Care - methods</topic><topic>Perinatal Care - statistics & numerical data</topic><topic>Platelet Count - methods</topic><topic>Platelet Function Tests - methods</topic><topic>Postpartum Hemorrhage - blood</topic><topic>Postpartum Hemorrhage - etiology</topic><topic>Postpartum Hemorrhage - therapy</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Chang</creatorcontrib><creatorcontrib>Li, YunHui</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Wang, QiuShi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Chang</au><au>Li, YunHui</au><au>Zhang, Wen</au><au>Wang, QiuShi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of perinatal coagulation function in preeclampsia</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-07-02</date><risdate>2021</risdate><volume>100</volume><issue>26</issue><spage>e26482</spage><epage>e26482</epage><pages>e26482-e26482</pages><issn>0025-7974</issn><issn>1536-5964</issn><eissn>1536-5964</eissn><abstract>To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE).The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed.Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P < .05). APTT and FIB in PE patients were lower in the day 1 postpartum group than in the prenatal and postpartum day 3 groups, and TT, DD, and fibrin degradation products (FDP) were higher (P < .05). PCT and MPV were highest in the prenatal group (P < .05).Compared with that of healthy pregnant women, the coagulation function of PE patients is in a relatively low-coagulation and high-fibrinolysis state on postpartum day 1, which increases the risk of postpartum hemorrhage and other adverse outcomes.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34190173</pmid><doi>10.1097/MD.0000000000026482</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Blood Coagulation - physiology Blood Coagulation Tests - methods China - epidemiology Female Fibrin Fibrinogen Degradation Products - analysis Fibrinolysis - physiology Humans Observational Study Perinatal Care - methods Perinatal Care - statistics & numerical data Platelet Count - methods Platelet Function Tests - methods Postpartum Hemorrhage - blood Postpartum Hemorrhage - etiology Postpartum Hemorrhage - therapy Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - physiopathology Pregnancy Pregnancy Outcome - epidemiology |
| title | Analysis of perinatal coagulation function in preeclampsia |
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