Proteogenomics drives therapeutic hypothesis generation for precision oncology

Summary Precision oncology has largely been driven by genomic profiling, but success so far has been limited. By combining genomic and proteomic analyses of tumours, proteogenomics holds promise in providing deeper mechanistic insights and generating therapeutic hypotheses to better match patients t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2021-07, Vol.125 (1), p.1-3
Hauptverfasser:	Lei, Jonathan T., Zhang, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2164 631/67/1536 631/67/1857 Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cancer therapies Clinical trials Comment Consortia Drug Resistance Drugs Epidemiology Gene expression Gene Expression Profiling Genomes Genomics Human papillomavirus Humans Hypotheses Mass Spectrometry Medical research Molecular Medicine Molecular Targeted Therapy Mutation Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Oncology Patients Precision Medicine Proteins Proteogenomics - methods Proteomics Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Precision oncology has largely been driven by genomic profiling, but success so far has been limited. By combining genomic and proteomic analyses of tumours, proteogenomics holds promise in providing deeper mechanistic insights and generating therapeutic hypotheses to better match patients to targeted treatments than analysing each ‘ome in isolation.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/s41416-021-01346-5