Characterizing distant metastases and survival in oropharyngeal squamous cell carcinoma

Characterizing distant metastases and survival in oropharyngeal squamous cell carcinoma

Background Outcomes of oropharyngeal squamous cell carcinoma (OPSCC) after development of distant metastases (DM) in the context of human papillomavirus (HPV) tumor status remain controversial in the literature. Methods OPSCC patients with DM treated between June 2015 and March 2019 were included fr...

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Veröffentlicht in:Head & neck 2021-07, Vol.43 (7), p.2101-2109
Hauptverfasser: Saiyed, Faiez K., Guo, Theresa, Johnson, Faye, Myers, Jeffrey N.
Format: Artikel
Sprache:eng
Schlagworte:
Carcinoma, Squamous Cell - therapy
Cell survival
distant metastases
Head and neck
Head and Neck Neoplasms
HPV
Human papillomavirus
Humans
Medical prognosis
Metastases
Metastasis
OPSCC
Original
Oropharyngeal Neoplasms - therapy
oropharyngeal squamous cell carcinoma
p16
Papillomaviridae
Papillomavirus Infections - complications
Prognosis
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Throat cancer
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Zusammenfassung:Background Outcomes of oropharyngeal squamous cell carcinoma (OPSCC) after development of distant metastases (DM) in the context of human papillomavirus (HPV) tumor status remain controversial in the literature. Methods OPSCC patients with DM treated between June 2015 and March 2019 were included from a prospectively enrolled database. Characteristics of DM including sites, episodes, and timing of disease were analyzed in addition to survival after DM. Results Sixty‐nine HPV‐positive and 18 HPV‐negative OPSCC patients with DM were included. The 2‐year survival after DM was higher for HPV‐positive patients (54.0% vs. 11.3%, p 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26678