Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different...
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Veröffentlicht in: | Angewandte Chemie International Edition 2021-06, Vol.60 (27), p.14750-14759 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different parameters and methods are reported to describe the experiments. The variation in the reported parameters can lead to problems with the reproducibility of the reported electroorganic syntheses. As an example, parameters such as current density or electrode distance are in some cases more significant than often anticipated. This Minireview provides guidelines on reporting electrosynthetic data and dispels myths about this technique, thereby streamlining the experimental parameters to facilitate reproducibility.
Organic transformations using electric current as a sustainable activator are a rapidly developing interdisciplinary field. However, different scientific backgrounds have led to a loss of important information being reported. Several pitfalls and misunderstandings regarding important parameters exist, which can cause challenges in reproducibility, even though electrical current is able to dial‐in various reactivities. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.202014544 |