Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction
Background Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures. Aims The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index...
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| Veröffentlicht in: | Aging clinical and experimental research 2021-07, Vol.33 (7), p.1875-1883 |
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| creator | Cammalleri, Valeria Bonanni, Michela Bueti, Francesca Maria Matteucci, Andrea Cammalleri, Lisa Stifano, Giuseppe Muscoli, Saverio Romeo, Francesco |
| description | Background
Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures.
Aims
The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index (MPI) in elderly with AMI.
Methods
A total of 241 patients ≥ 65 years old with AMI were continuously enrolled in this prospective study and divided into three groups according to the MPI score. The primary endpoint was 30-day mortality. Secondary endpoints were 6-month mortality and rate of adverse events.
Results
In-hospital overall mortality rate was higher in MPI-3 (
p
= 0.009). Patients of MPI-3 had a significantly higher mortality rate regarding the primary endpoint with 30-day survival of 78.9%, compared to 97.4% and 97.2%, in MPI-1, MPI-2 (
p
|
| doi_str_mv | 10.1007/s40520-020-01718-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8249274</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2447841057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-b020ce24a35e13f18c3c2cfea3deb6f711d22a19fd41c2e41a833575378a77ce3</originalsourceid><addsrcrecordid>eNp9kU1PGzEQhq0KVCjlD_RQWeqFHpZ6bG-8uVRCiI9IIDi0NyTL8c4Go1072N6W_HschVLgwGFkj-aZ1zN-CfkC7BAYUz-SZDVnFVsHKGiqyQeyC6qkjYDp1ov7DvmU0h1jEkrykewIwRhIJnbJzeXYZ9e6AX1ywZueXsew8CFlZ-nMt_hADy6vZ9-p8xT7FmO_okuTHfqc6F-Xb6mxY0Y6rII1sXVFwPnORJuL2mey3Zk-4f7TuUd-n578Oj6vLq7OZsdHF5WVSuZqXjawyKURNYLooLHCctuhES3OJ50CaDk3MO1aCZajBNMIUataqMYoZVHskZ8b3eU4H7C1Zbhoer2MbjBxpYNx-nXFu1u9CH90w-WUK1kEDp4EYrgfMWU9uGSx743HMCbNpVSNBFargn57g96FMZaPK1QtFaipEE2h-IayMaQUsXseBphem6c35mm2jrV5elKavr5c47nln1sFEBsglZJfYPz_9juyj5yAph8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2547179338</pqid></control><display><type>article</type><title>Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Cammalleri, Valeria ; Bonanni, Michela ; Bueti, Francesca Maria ; Matteucci, Andrea ; Cammalleri, Lisa ; Stifano, Giuseppe ; Muscoli, Saverio ; Romeo, Francesco</creator><creatorcontrib>Cammalleri, Valeria ; Bonanni, Michela ; Bueti, Francesca Maria ; Matteucci, Andrea ; Cammalleri, Lisa ; Stifano, Giuseppe ; Muscoli, Saverio ; Romeo, Francesco</creatorcontrib><description>Background
Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures.
Aims
The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index (MPI) in elderly with AMI.
Methods
A total of 241 patients ≥ 65 years old with AMI were continuously enrolled in this prospective study and divided into three groups according to the MPI score. The primary endpoint was 30-day mortality. Secondary endpoints were 6-month mortality and rate of adverse events.
Results
In-hospital overall mortality rate was higher in MPI-3 (
p
= 0.009). Patients of MPI-3 had a significantly higher mortality rate regarding the primary endpoint with 30-day survival of 78.9%, compared to 97.4% and 97.2%, in MPI-1, MPI-2 (
p
< 0.001), respectively. The survival rate progressively decreased in the three MPI classes of risk with a 6-month survival of 96.5%, 96.3%, 73.7% in groups MPI-1, MPI-2, and MPI-3 (
p
< 0.001). Longer length of in-hospital stay was observed in MPI-3 group. In-hospital complications were more frequent in higher MPI score.
Discussion
Our findings are in agreement with the results of other studies that evaluated the risk of in-hospital complications and mortality in older patients. In our “real-world” population of elderly hospitalized for AMI we observed poorer outcomes in patients belonged to higher MPI groups.
Conclusions
In the setting of AMI, MPI may be very useful in the daily clinical practice to manage older patients and predict the risk of in-hospital and follow-up complications.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-020-01718-6</identifier><identifier>PMID: 33001403</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Geriatric Assessment ; Geriatrics/Gerontology ; Heart attacks ; Humans ; Length of Stay ; Medicine ; Medicine & Public Health ; Mortality ; Myocardial Infarction ; Original ; Original Article ; Prognosis ; Prospective Studies ; Risk Factors</subject><ispartof>Aging clinical and experimental research, 2021-07, Vol.33 (7), p.1875-1883</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b020ce24a35e13f18c3c2cfea3deb6f711d22a19fd41c2e41a833575378a77ce3</citedby><cites>FETCH-LOGICAL-c474t-b020ce24a35e13f18c3c2cfea3deb6f711d22a19fd41c2e41a833575378a77ce3</cites><orcidid>0000-0001-5374-8125</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-020-01718-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-020-01718-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33001403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cammalleri, Valeria</creatorcontrib><creatorcontrib>Bonanni, Michela</creatorcontrib><creatorcontrib>Bueti, Francesca Maria</creatorcontrib><creatorcontrib>Matteucci, Andrea</creatorcontrib><creatorcontrib>Cammalleri, Lisa</creatorcontrib><creatorcontrib>Stifano, Giuseppe</creatorcontrib><creatorcontrib>Muscoli, Saverio</creatorcontrib><creatorcontrib>Romeo, Francesco</creatorcontrib><title>Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures.
Aims
The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index (MPI) in elderly with AMI.
Methods
A total of 241 patients ≥ 65 years old with AMI were continuously enrolled in this prospective study and divided into three groups according to the MPI score. The primary endpoint was 30-day mortality. Secondary endpoints were 6-month mortality and rate of adverse events.
Results
In-hospital overall mortality rate was higher in MPI-3 (
p
= 0.009). Patients of MPI-3 had a significantly higher mortality rate regarding the primary endpoint with 30-day survival of 78.9%, compared to 97.4% and 97.2%, in MPI-1, MPI-2 (
p
< 0.001), respectively. The survival rate progressively decreased in the three MPI classes of risk with a 6-month survival of 96.5%, 96.3%, 73.7% in groups MPI-1, MPI-2, and MPI-3 (
p
< 0.001). Longer length of in-hospital stay was observed in MPI-3 group. In-hospital complications were more frequent in higher MPI score.
Discussion
Our findings are in agreement with the results of other studies that evaluated the risk of in-hospital complications and mortality in older patients. In our “real-world” population of elderly hospitalized for AMI we observed poorer outcomes in patients belonged to higher MPI groups.
Conclusions
In the setting of AMI, MPI may be very useful in the daily clinical practice to manage older patients and predict the risk of in-hospital and follow-up complications.</description><subject>Aged</subject><subject>Geriatric Assessment</subject><subject>Geriatrics/Gerontology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Myocardial Infarction</subject><subject>Original</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1PGzEQhq0KVCjlD_RQWeqFHpZ6bG-8uVRCiI9IIDi0NyTL8c4Go1072N6W_HschVLgwGFkj-aZ1zN-CfkC7BAYUz-SZDVnFVsHKGiqyQeyC6qkjYDp1ov7DvmU0h1jEkrykewIwRhIJnbJzeXYZ9e6AX1ywZueXsew8CFlZ-nMt_hADy6vZ9-p8xT7FmO_okuTHfqc6F-Xb6mxY0Y6rII1sXVFwPnORJuL2mey3Zk-4f7TuUd-n578Oj6vLq7OZsdHF5WVSuZqXjawyKURNYLooLHCctuhES3OJ50CaDk3MO1aCZajBNMIUataqMYoZVHskZ8b3eU4H7C1Zbhoer2MbjBxpYNx-nXFu1u9CH90w-WUK1kEDp4EYrgfMWU9uGSx743HMCbNpVSNBFargn57g96FMZaPK1QtFaipEE2h-IayMaQUsXseBphem6c35mm2jrV5elKavr5c47nln1sFEBsglZJfYPz_9juyj5yAph8</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Cammalleri, Valeria</creator><creator>Bonanni, Michela</creator><creator>Bueti, Francesca Maria</creator><creator>Matteucci, Andrea</creator><creator>Cammalleri, Lisa</creator><creator>Stifano, Giuseppe</creator><creator>Muscoli, Saverio</creator><creator>Romeo, Francesco</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5374-8125</orcidid></search><sort><creationdate>20210701</creationdate><title>Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction</title><author>Cammalleri, Valeria ; Bonanni, Michela ; Bueti, Francesca Maria ; Matteucci, Andrea ; Cammalleri, Lisa ; Stifano, Giuseppe ; Muscoli, Saverio ; Romeo, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b020ce24a35e13f18c3c2cfea3deb6f711d22a19fd41c2e41a833575378a77ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Geriatric Assessment</topic><topic>Geriatrics/Gerontology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Myocardial Infarction</topic><topic>Original</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cammalleri, Valeria</creatorcontrib><creatorcontrib>Bonanni, Michela</creatorcontrib><creatorcontrib>Bueti, Francesca Maria</creatorcontrib><creatorcontrib>Matteucci, Andrea</creatorcontrib><creatorcontrib>Cammalleri, Lisa</creatorcontrib><creatorcontrib>Stifano, Giuseppe</creatorcontrib><creatorcontrib>Muscoli, Saverio</creatorcontrib><creatorcontrib>Romeo, Francesco</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cammalleri, Valeria</au><au>Bonanni, Michela</au><au>Bueti, Francesca Maria</au><au>Matteucci, Andrea</au><au>Cammalleri, Lisa</au><au>Stifano, Giuseppe</au><au>Muscoli, Saverio</au><au>Romeo, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>33</volume><issue>7</issue><spage>1875</spage><epage>1883</epage><pages>1875-1883</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Management of elderly patients with acute myocardial infarction (AMI) is challenging due to lack of knowledge about the link between fragility, outcomes and interventional procedures.
Aims
The aim of this study was to establish the prognostic role of the Multidimensional Prognostic Index (MPI) in elderly with AMI.
Methods
A total of 241 patients ≥ 65 years old with AMI were continuously enrolled in this prospective study and divided into three groups according to the MPI score. The primary endpoint was 30-day mortality. Secondary endpoints were 6-month mortality and rate of adverse events.
Results
In-hospital overall mortality rate was higher in MPI-3 (
p
= 0.009). Patients of MPI-3 had a significantly higher mortality rate regarding the primary endpoint with 30-day survival of 78.9%, compared to 97.4% and 97.2%, in MPI-1, MPI-2 (
p
< 0.001), respectively. The survival rate progressively decreased in the three MPI classes of risk with a 6-month survival of 96.5%, 96.3%, 73.7% in groups MPI-1, MPI-2, and MPI-3 (
p
< 0.001). Longer length of in-hospital stay was observed in MPI-3 group. In-hospital complications were more frequent in higher MPI score.
Discussion
Our findings are in agreement with the results of other studies that evaluated the risk of in-hospital complications and mortality in older patients. In our “real-world” population of elderly hospitalized for AMI we observed poorer outcomes in patients belonged to higher MPI groups.
Conclusions
In the setting of AMI, MPI may be very useful in the daily clinical practice to manage older patients and predict the risk of in-hospital and follow-up complications.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33001403</pmid><doi>10.1007/s40520-020-01718-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5374-8125</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Geriatric Assessment Geriatrics/Gerontology Heart attacks Humans Length of Stay Medicine Medicine & Public Health Mortality Myocardial Infarction Original Original Article Prognosis Prospective Studies Risk Factors |
| title | Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction |
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