Pralatrexate for refractory mycosis fungoides in two Japanese patients

Pralatrexate for refractory mycosis fungoides in two Japanese patients

Pralatrexate has been approved for the treatment of relapsed/refractory peripheral T cell lymphomas. Studies in the U.S. also support the clinical efficacy of pralatrexate to treat advanced‐stage cutaneous T‐cell lymphomas, but outcomes in Japanese patients have not yet been reported. We herein desc...

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Veröffentlicht in:Journal of dermatology 2021-05, Vol.48 (5), p.667-671
Hauptverfasser: Teraishi, Mika, Oguro, Tokuko, Kusume, Ema, Kobashi, Haruka, Sano, Hozumi, Fujioka, Ai, Yamamoto, Mayuko, Nakajima, Hideki, Sano, Shigetoshi
Format: Artikel
Sprache:eng
Schlagworte:
Aminopterin - analogs & derivatives
Case reports
Chemotherapy
Clinical outcomes
Concise Communication
Concise Communications
cutaneous T‐cell lymphoma
Fungal infections
Humans
Japan
Lymphocytes T
Lymphoma
Mycosis
Mycosis fungoides
Mycosis Fungoides - drug therapy
Neoplasm Recurrence, Local
Patients
pralatrexate
refractory mycosis fungoides
Skin Neoplasms - drug therapy
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Zusammenfassung:Pralatrexate has been approved for the treatment of relapsed/refractory peripheral T cell lymphomas. Studies in the U.S. also support the clinical efficacy of pralatrexate to treat advanced‐stage cutaneous T‐cell lymphomas, but outcomes in Japanese patients have not yet been reported. We herein describe two Japanese patients with heavily‐pretreated relapsed/refractory mycosis fungoides that were successfully controlled by pralatrexate.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.15761