Plasma biomarker factors associated with neurodevelopmental outcomes in children with perinatal HIV infection and controlled viremia

We examined relationships between plasma biomarkers and neurodevelopment in children from sub-Saharan Africa with perinatal HIV (PHIV) with controlled viremia on antiretroviral therapy (ART). Longitudinal retrospective cohort study of children with controlled blood HIV replication. Children (N = 213...

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Veröffentlicht in:	AIDS (London) 2021-07, Vol.35 (9), p.1375-1384
Hauptverfasser:	Kapetanovic, Suad, Giganti, Mark J., Abzug, Mark J., Lindsey, Jane C., Sirois, Patricia A., Montepiedra, Grace, Canniff, Jennifer, Agwu, Allison, Boivin, Michael J., Weinberg, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - blood Child Child, Preschool Female HIV Infections - complications HIV Infections - drug therapy Humans Male Neurodevelopmental Disorders - virology Pregnancy Retrospective Studies Viremia
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Beschreibung
Zusammenfassung:	We examined relationships between plasma biomarkers and neurodevelopment in children from sub-Saharan Africa with perinatal HIV (PHIV) with controlled viremia on antiretroviral therapy (ART). Longitudinal retrospective cohort study of children with controlled blood HIV replication. Children (N = 213; 57% girls) started ART at less than 3 years of age, had neurodevelopmental assessments (cognition, attention/impulsivity, motor proficiency, global executive functions) at 5-11 years, and achieved controlled viremia (HIV-1 RNA
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000002862