Genome‐wide analysis of SARS‐CoV‐2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation

Genome‐wide analysis of SARS‐CoV‐2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation

Genome‐wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID‐19) cases and outbreaks. We performed whole‐genome sequencing of 27 SARS‐CoV‐2 strains isolated betwee...

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Veröffentlicht in:Journal of medical virology 2021-09, Vol.93 (9), p.5660-5665
Hauptverfasser: Dao, Manh H., Phan, Lan T., Cao, Thang M., Luong, Quang C., Pham, Hang T. T., Vu, Nhung H. P., Khuu, Nghia V., Nguyen, Thinh V., Nguyen, Long T., Nguyen, Hieu T., Nguyen, Anh H., Huynh, Loan Kim Thi, Huynh, Thao P., Nguyen, Quan H., Truong, Hieu C., Nguyen, Hang Minh, Trinh, Tung Xuan, Nguyen, Dung T., Nguyen, Trieu B., Do, Hung T., Pham, Quang D., Nguyen, Thuong V.
Format: Artikel
Sprache:eng
Schlagworte:
Confidence intervals
Contact tracing
Coronaviruses
COVID-19
D614G
Disease transmission
Epidemics
Epidemiology
Gene sequencing
Genomes
Infectivity
Mutation
next‐generation sequencing
Polymerase chain reaction
Quarantine
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Short Communication
Vietnam
Viral diseases
Virology
Virulence
Whole genome sequencing
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Zusammenfassung:Genome‐wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID‐19) cases and outbreaks. We performed whole‐genome sequencing of 27 SARS‐CoV‐2 strains isolated between January 2020 and April 2020. A total of 54 mutations in different genomic regions was found. The D614G mutation, first detected in March 2020, was identified in 18 strains and was more likely associated with a lower cycle threshold (
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27103