Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Naive Nursing Home Residents

Abstract After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–naive nursing home residents’ me...

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Veröffentlicht in:	Clinical infectious diseases 2021-12, Vol.73 (11), p.2112-2115
Hauptverfasser:	Canaday, David H, Carias, Lenore, Oyebanji, Oladayo A, Keresztesy, Debbie, Wilk, Dennis, Payne, Michael, Aung, Htin, St. Denis, Kerri, Lam, Evan C, Rowley, Christopher F, Berry, Sarah D, Cameron, Cheryl M, Cameron, Mark J, Wilson, Brigid, Balazs, Alejandro B, Gravenstein, Stefan, King, Christopher L
Format:	Artikel
Sprache:	eng
Schlagworte:	BNT162 Vaccine Brief Reports COVID-19 COVID-19 Vaccines Humans mRNA Vaccines Nursing Homes RNA, Messenger SARS-CoV-2 Vaccines, Synthetic
Online-Zugang:	Volltext
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Zusammenfassung:	Abstract After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–naive nursing home residents’ median post–second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2–naive healthcare workers.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciab447