Glioma EVs Contribute to Immune Privilege in the Brain

Glioma EVs Contribute to Immune Privilege in the Brain

Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune mod...

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Veröffentlicht in:Trends in Cancer 2019-07, Vol.5 (7), p.393-396
Hauptverfasser: Abels, Erik R, Broekman, Marike L D, Breakefield, Xandra O, Maas, Sybren L N
Format: Artikel
Sprache:eng
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Zusammenfassung:Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.
ISSN:2405-8033
2405-8025
DOI:10.1016/j.trecan.2019.05.006