HCC in the Era of Direct-Acting Antiviral Agents (DAAs): Surgical and Other Curative or Palliative Strategies in the Elderly

HCC in the Era of Direct-Acting Antiviral Agents (DAAs): Surgical and Other Curative or Palliative Strategies in the Elderly

Hepatocellular carcinoma (HCC) accounts for 75–85% of primary liver malignancies, and elderlies have the highest incidence rates. Direct-acting antiviral agents (DAAs) have shown satisfying results in terms of HCV sustained viral response (SVR). However, data regarding HCC risk post-DAA-SVR is still...

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Veröffentlicht in:Cancers 2021-06, Vol.13 (12), p.3025
Hauptverfasser: Brozzetti, Stefania, Tancredi, Marsia, Bini, Simone, De Lucia, Chiara, Antimi, Jessica, D’Alterio, Chiara, De Sanctis, Giuseppe Maria, Furlan, Caterina, Malpassuti, Vittoria Carolina, Lucatelli, Pierleone, Di Martino, Michele, Bezzi, Mario, Ciardi, Antonio, Pascale, Rosa Maria
Format: Artikel
Sprache:eng
Schlagworte:
Ablation
Age
Antiviral agents
Biopsy
Cancer therapies
Cardiovascular disease
Cirrhosis
Death
Diabetes
Drug resistance
Eradication
Fibrosis
Hepatitis C
Hepatocellular carcinoma
Immune clearance
Immune response
Infections
Interferon
Laboratories
Liver cancer
Liver cirrhosis
Liver diseases
Localization
Males
Mortality
Palliation
Ribavirin
Statistical analysis
Surgery
Ultrasonic imaging
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Zusammenfassung:Hepatocellular carcinoma (HCC) accounts for 75–85% of primary liver malignancies, and elderlies have the highest incidence rates. Direct-acting antiviral agents (DAAs) have shown satisfying results in terms of HCV sustained viral response (SVR). However, data regarding HCC risk post-DAA-SVR is still conflicting. This study aims to consider HCC onset in moderate underlying liver disease. We conducted a retrospective study on 227 chronically infected patients (cHCV), treated with DAAs. Patients were divided into three groups: “de novo occurrent HCC”, “recurrent HCC”, and “without HCC”. Fifty-six patients aged
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13123025