Circulating blood cellular glucose transporters – Surrogate biomarkers for neonatal hypoxic-ischemic encephalopathy assessed by novel scoring systems

We examined Red Blood Cell (RBC) Glucose Transporter isoform 1 (GLUT1) and White Blood Cell (WBC) Glucose Transporter isoform 3 (GLUT3) protein concentrations to assess their potential as surrogate biomarkers for the presence of hypoxic-ischemic encephalopathy (HIE) and response to therapeutic hypot...

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Veröffentlicht in:	Molecular genetics and metabolism 2019-06, Vol.127 (2), p.166-173
Hauptverfasser:	Maggiotto, Liesbeth V., Sondhi, Monica, Shin, Bo-Chul, Garg, Meena, Devaskar, Sherin U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Brain injury Erythrocytes - metabolism Feasibility Studies Female Glial Fibrillary Acidic Protein - metabolism Glucose Transporter Type 1 - metabolism Glucose Transporter Type 3 - metabolism Glucose transporters HIE Humans Hypoxia-Ischemia, Brain - diagnosis Infant, Newborn Intensive Care Units, Neonatal Male Phosphopyruvate Hydratase - metabolism Pilot Projects Prognosis Prospective Studies Red blood cells Sensitivity and Specificity Severity of Illness Index Therapeutic hypothermia
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Zusammenfassung:	We examined Red Blood Cell (RBC) Glucose Transporter isoform 1 (GLUT1) and White Blood Cell (WBC) Glucose Transporter isoform 3 (GLUT3) protein concentrations to assess their potential as surrogate biomarkers for the presence of hypoxic-ischemic encephalopathy (HIE) and response to therapeutic hypothermia (TH), with respect to the neurodevelopmental prognosis. A prospective feasibility study of 10 infants with HIE and 8 age-matched control subjects was undertaken. Following parental consent, blood samples were obtained at baseline before institution of TH (
ISSN:	1096-7192 1096-7206
DOI:	10.1016/j.ymgme.2019.05.013