Variants in AGTR2 gene in Maya people with COVID-19

•Mexico is the fourth place in lethality for COVID-19 infection.•A variant located in AGTR2 gene was associated to T2DM in Maya from Yucatan.•People from Yucatan have a higher risk of lethality among Mexicans.•AGTR2 is highly expressed in lung.•An AGTR2 agonist is under study to fight against lethal...

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Veröffentlicht in:	Gene 2021-08, Vol.795, p.145794-145794, Article 145794
Hauptverfasser:	Totomoch-Serra, Armando, Domínguez-Cruz, Miriam Givisay, Manterola, C., Muñoz, Maria de Lourdes
Format:	Artikel
Sprache:	eng
Schlagworte:	AGTR2 gene Angiotensin II Receptor Type 2 C21 drug Covid-19 COVID-19 - genetics Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Genetic Predisposition to Disease Humans Indigenous Peoples - genetics Letter to the Editor Maya population Mexico Pilot GWAS study Polymorphism, Single Nucleotide Receptor, Angiotensin, Type 2 - genetics SARS-CoV-2 Single nucleotide polymorphism Yucatan
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Zusammenfassung:	•Mexico is the fourth place in lethality for COVID-19 infection.•A variant located in AGTR2 gene was associated to T2DM in Maya from Yucatan.•People from Yucatan have a higher risk of lethality among Mexicans.•AGTR2 is highly expressed in lung.•An AGTR2 agonist is under study to fight against lethality in COVID-19 infection.
ISSN:	0378-1119 1879-0038 1879-0038
DOI:	10.1016/j.gene.2021.145794