Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity

Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity

Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles...

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Veröffentlicht in:Trends in immunology 2020-09, Vol.41 (9), p.753-755
Hauptverfasser: Rosenberg, Marci F., Molofsky, Anna V.
Format: Artikel
Sprache:eng
Schlagworte:
Astrocytes
Brain
Crosstalk
Fibroblasts
Gene expression
Heterogeneity
Immune system
Morphology
Researchers
Transcription factors
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Zusammenfassung:Huang et al. have found that deletion of astrocyte lineage-specifying transcription factor NFIA from mature astrocytes alters astrocyte morphology, molecular identity, and synaptic-support capacity in a region-specific manner. We discuss the implications of these findings in light of emerging roles for astrocytes in immune cell crosstalk.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2020.07.011