Association between IL-18 and IL-6 gene polymorphisms and the risk of T1D in Egyptian children

Association between IL-18 and IL-6 gene polymorphisms and the risk of T1D in Egyptian children

Purpose To test the involvement between IL-18 and IL-6 genetic polymorphisms and susceptibility to Type 1 diabetes (T1D). Methods Single nucleotide polymorphisms (SNPs) at positions −607A/C and − 137G/C in IL-18 promoter region were examined by sequence specific primers-polymerase chain reaction (SS...

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Veröffentlicht in:Journal of diabetes and metabolic disorders 2021-06, Vol.20 (1), p.439-446
Hauptverfasser: Ali, Yasser B. M., El-Gahel, Hend E., Abdel-Hakem, Nehal E., Gadalla, Mahmoud E., El-Hefnawy, Mohamed H., El-Shahat, Mohamed
Format: Artikel
Sprache:eng
Schlagworte:
Comparative analysis
Diabetes
Disease susceptibility
Endocrinology
Genes
Genetic aspects
Genetic research
Glycosylated hemoglobin
Medicine
Medicine & Public Health
Metabolic Diseases
Research Article
Scientific equipment and supplies industry
Single nucleotide polymorphisms
Type 1 diabetes
Type 2 diabetes
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Zusammenfassung:Purpose To test the involvement between IL-18 and IL-6 genetic polymorphisms and susceptibility to Type 1 diabetes (T1D). Methods Single nucleotide polymorphisms (SNPs) at positions −607A/C and − 137G/C in IL-18 promoter region were examined by sequence specific primers-polymerase chain reaction (SSP-PCR) and position -174G/C in promoter region of IL-6 gene which analyzed by Mutagenically Separated PCR (MS-PCR) in 104 T1D participants and 114 controls. Results IL-18 -137GC and -137CC genotypes and -137C allele were significantly decreased in T1D subjects ( P  
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-021-00763-w