Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists

Morphine is widely used in pain management although the risk of side effects is significant. The use of biased agonists to the G protein of μ-opioid receptors has been suggested as a potential solution, although oliceridine and PZM21 have previously failed to demonstrate benefits in clinical studies...

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Veröffentlicht in:	ACS pharmacology & translational science 2021-06, Vol.4 (3), p.1149-1160
Hauptverfasser:	Lee, Jin Hee, Shon, Suh-Youn, Jeon, Woojin, Hong, Sung-Jun, Ban, Junsu, Lee, Do Sup
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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