Optimal serum ferritin level range: iron status measure and inflammatory biomarker

Optimal serum ferritin level range: iron status measure and inflammatory biomarker

This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomiz...

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Veröffentlicht in:Metallomics 2021-06, Vol.13 (6)
Hauptverfasser: DePalma, Ralph G, Hayes, Virginia W, O'Leary, Timothy J
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Hayes, Virginia W
O'Leary, Timothy J
description This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomized study using phlebotomy in patients with peripheral arterial disease offered unique insights into dual roles of serum ferritin both as an iron status marker and acute phase reactant. Robust positive associations between serum ferritin, interleukin 6 [IL-6], tissue necrosis factor-alpha, and high sensitivity C-reactive protein were discovered. Elevated serum ferritin and IL-6 levels associated with increased mortality and with reduced mortality at ferritin levels
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Based upon experimental and epidemiologic data, we suggest testing the hypotheses that optimal ferritin levels for cardiovascular mortality reduction range from 20 to 100 ng mL−1 with % transferrin levels from 20 to 50%, to ensure adequate iron status and that ferritin levels above 194 ng mL−1 associate with all-cause mortality in population cohorts.</description><identifier>ISSN: 1756-591X</identifier><identifier>ISSN: 1756-5901</identifier><identifier>EISSN: 1756-591X</identifier><identifier>DOI: 10.1093/mtomcs/mfab030</identifier><identifier>PMID: 34048587</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Metallomics, 2021-06, Vol.13 (6)</ispartof><rights>Published by Oxford University Press 2021. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-bb07d779da3467a8413f21d96dd624fdcce7afb273066a2e5fa4204e02e70bea3</citedby><cites>FETCH-LOGICAL-c367t-bb07d779da3467a8413f21d96dd624fdcce7afb273066a2e5fa4204e02e70bea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids></links><search><creatorcontrib>DePalma, Ralph G</creatorcontrib><creatorcontrib>Hayes, Virginia W</creatorcontrib><creatorcontrib>O'Leary, Timothy J</creatorcontrib><title>Optimal serum ferritin level range: iron status measure and inflammatory biomarker</title><title>Metallomics</title><description>This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. 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Based upon experimental and epidemiologic data, we suggest testing the hypotheses that optimal ferritin levels for cardiovascular mortality reduction range from 20 to 100 ng mL−1 with % transferrin levels from 20 to 50%, to ensure adequate iron status and that ferritin levels above 194 ng mL−1 associate with all-cause mortality in population cohorts.</abstract><pub>Oxford University Press</pub><pmid>34048587</pmid><doi>10.1093/mtomcs/mfab030</doi><oa>free_for_read</oa></addata></record>
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title Optimal serum ferritin level range: iron status measure and inflammatory biomarker
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