Optimal serum ferritin level range: iron status measure and inflammatory biomarker

This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomiz...

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Veröffentlicht in:Metallomics 2021-06, Vol.13 (6)
Hauptverfasser: DePalma, Ralph G, Hayes, Virginia W, O'Leary, Timothy J
Format: Artikel
Sprache:eng
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Zusammenfassung:This report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomized study using phlebotomy in patients with peripheral arterial disease offered unique insights into dual roles of serum ferritin both as an iron status marker and acute phase reactant. Robust positive associations between serum ferritin, interleukin 6 [IL-6], tissue necrosis factor-alpha, and high sensitivity C-reactive protein were discovered. Elevated serum ferritin and IL-6 levels associated with increased mortality and with reduced mortality at ferritin levels
ISSN:1756-591X
1756-5901
1756-591X
DOI:10.1093/mtomcs/mfab030