Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study
BACKGROUND:The longer-term risks of statins on physical function among people with HIV are unclear. METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2021-04, Vol.86 (4), p.455-462 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Abdo, Mona Langan, Susan J. MaWhinney, Samantha Sun, Jing Lake, Jordan E. Palella, Frank J. Kingsley, Lawrence Brown, Todd T. Erlandson, Kristine M. |
| description | BACKGROUND:The longer-term risks of statins on physical function among people with HIV are unclear.
METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction terms between 1) statin use and age and 2) HIV serostatus, age and statin use were considered to evaluate associations between statin use and physical function. Models were adjusted for demographics and cardiovascular risk factors.
RESULTS:Among 2,021 men (1,048 with HIV), baseline median age was 52 (IQR 46, 58) years; 636 were consistent, 398 intermittent, and 987 never statin users. There was a significant interaction between age, statin and HIV serostatus for gait speed. Among PWH, for every 5-year age increase, gait speed (m/sec) decline was marginally greater among consistent verses never statin users (-0.008 [95% CI -0.017, -0.00007]; p=0.048), with more notable differences between intermittent and never users (-0.017 [95% CI -0.027, -0.008]; p |
| doi_str_mv | 10.1097/QAI.0000000000002579 |
| format | Article |
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METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction terms between 1) statin use and age and 2) HIV serostatus, age and statin use were considered to evaluate associations between statin use and physical function. Models were adjusted for demographics and cardiovascular risk factors.
RESULTS:Among 2,021 men (1,048 with HIV), baseline median age was 52 (IQR 46, 58) years; 636 were consistent, 398 intermittent, and 987 never statin users. There was a significant interaction between age, statin and HIV serostatus for gait speed. Among PWH, for every 5-year age increase, gait speed (m/sec) decline was marginally greater among consistent verses never statin users (-0.008 [95% CI -0.017, -0.00007]; p=0.048), with more notable differences between intermittent and never users (-0.017 [95% CI -0.027, -0.008]; p<0.001). Similar results were observed among men without HIV. Significant differences in grip strength (kg) decline were seen between intermittent and never users (-0.53 [95% CI -0.98, -0.07]; p=0.024), differences between consistent and never users (-0.28 [95% CI -0.63, 0.06]; p=0.11) were not statistically significant.
CONCLUSION:Among men with and without HIV, intermittent statin users had more pronounced declines in physical function compared to consistent and never users. Consistent statin use does not appear to have a major impact on physical function in men with or without HIV.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0000000000002579</identifier><identifier>PMID: 33230030</identifier><language>eng</language><publisher>United States: JAIDS Journal of Acquired Immune Deficiency Syndromes</publisher><subject>Cohort Studies ; Hand Strength ; HIV Infections - complications ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hyperlipidemias - drug therapy ; Male ; Middle Aged ; Physical Functional Performance</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2021-04, Vol.86 (4), p.455-462</ispartof><rights>JAIDS Journal of Acquired Immune Deficiency Syndromes</rights><rights>Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5029-cb40c05d69e5931e4848721f672096053eadc550925c96f6feb83fc33fb78da3</citedby><cites>FETCH-LOGICAL-c5029-cb40c05d69e5931e4848721f672096053eadc550925c96f6feb83fc33fb78da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00126334-202104010-00013$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00126334-202104010-00013$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>230,314,780,784,885,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33230030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdo, Mona</creatorcontrib><creatorcontrib>Langan, Susan J.</creatorcontrib><creatorcontrib>MaWhinney, Samantha</creatorcontrib><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Lake, Jordan E.</creatorcontrib><creatorcontrib>Palella, Frank J.</creatorcontrib><creatorcontrib>Kingsley, Lawrence</creatorcontrib><creatorcontrib>Brown, Todd T.</creatorcontrib><creatorcontrib>Erlandson, Kristine M.</creatorcontrib><title>Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>BACKGROUND:The longer-term risks of statins on physical function among people with HIV are unclear.
METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction terms between 1) statin use and age and 2) HIV serostatus, age and statin use were considered to evaluate associations between statin use and physical function. Models were adjusted for demographics and cardiovascular risk factors.
RESULTS:Among 2,021 men (1,048 with HIV), baseline median age was 52 (IQR 46, 58) years; 636 were consistent, 398 intermittent, and 987 never statin users. There was a significant interaction between age, statin and HIV serostatus for gait speed. Among PWH, for every 5-year age increase, gait speed (m/sec) decline was marginally greater among consistent verses never statin users (-0.008 [95% CI -0.017, -0.00007]; p=0.048), with more notable differences between intermittent and never users (-0.017 [95% CI -0.027, -0.008]; p<0.001). Similar results were observed among men without HIV. Significant differences in grip strength (kg) decline were seen between intermittent and never users (-0.53 [95% CI -0.98, -0.07]; p=0.024), differences between consistent and never users (-0.28 [95% CI -0.63, 0.06]; p=0.11) were not statistically significant.
CONCLUSION:Among men with and without HIV, intermittent statin users had more pronounced declines in physical function compared to consistent and never users. Consistent statin use does not appear to have a major impact on physical function in men with or without HIV.</description><subject>Cohort Studies</subject><subject>Hand Strength</subject><subject>HIV Infections - complications</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Physical Functional Performance</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhSMEoqXwBgh5ySbFv0m8QYqGlo7UClBHsLQ8zvUkkLGntkM1z8BL4zClKizAG1_pfufcKx8XxUuCTwmW9ZtP7fIUPzhU1PJRcUwk52XdNPxxrgUVJSdMHBXPYvyKMak4l0-LI8Yow5jh4-LHmbVgEvIWXSedBodWPQS92yPvULuBso3Rm0En6NCi124DEWXoY7-Pg9EjOp-cScPMbr3boCtw6MuQeqRd96vwU0IXy8-zJvWArqYxDQZcgoDa5btrtPC9DynPnrr98-KJ1WOEF3f3SbE6P1stLsrLD--Xi_ayNAJTWZo1xwaLrpIgJCPAG97UlNiqplhWWDDQnRECSyqMrGxlYd0waxiz67rpNDsp3h5sd9N6C928TdCj2oVhq8NeeT2oPztu6NXGf1cNkUziJhu8vjMI_maCmNR2iAbGUTvwU1SUV5zwSooZ5QfUBB9jAHs_hmA1x6hyjOrvGLPs1cMV70W_c8tAcwBu_ZjfMn4bp1sIqgc9pv5_3vwf0vxHaMUYLymmBHNMcJmFhLGfVSu5sA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Abdo, Mona</creator><creator>Langan, Susan J.</creator><creator>MaWhinney, Samantha</creator><creator>Sun, Jing</creator><creator>Lake, Jordan E.</creator><creator>Palella, Frank J.</creator><creator>Kingsley, Lawrence</creator><creator>Brown, Todd T.</creator><creator>Erlandson, Kristine M.</creator><general>JAIDS Journal of Acquired Immune Deficiency Syndromes</general><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210401</creationdate><title>Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study</title><author>Abdo, Mona ; Langan, Susan J. ; MaWhinney, Samantha ; Sun, Jing ; Lake, Jordan E. ; Palella, Frank J. ; Kingsley, Lawrence ; Brown, Todd T. ; Erlandson, Kristine M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5029-cb40c05d69e5931e4848721f672096053eadc550925c96f6feb83fc33fb78da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cohort Studies</topic><topic>Hand Strength</topic><topic>HIV Infections - complications</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Physical Functional Performance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdo, Mona</creatorcontrib><creatorcontrib>Langan, Susan J.</creatorcontrib><creatorcontrib>MaWhinney, Samantha</creatorcontrib><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Lake, Jordan E.</creatorcontrib><creatorcontrib>Palella, Frank J.</creatorcontrib><creatorcontrib>Kingsley, Lawrence</creatorcontrib><creatorcontrib>Brown, Todd T.</creatorcontrib><creatorcontrib>Erlandson, Kristine M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdo, Mona</au><au>Langan, Susan J.</au><au>MaWhinney, Samantha</au><au>Sun, Jing</au><au>Lake, Jordan E.</au><au>Palella, Frank J.</au><au>Kingsley, Lawrence</au><au>Brown, Todd T.</au><au>Erlandson, Kristine M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>86</volume><issue>4</issue><spage>455</spage><epage>462</epage><pages>455-462</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><abstract>BACKGROUND:The longer-term risks of statins on physical function among people with HIV are unclear.
METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction terms between 1) statin use and age and 2) HIV serostatus, age and statin use were considered to evaluate associations between statin use and physical function. Models were adjusted for demographics and cardiovascular risk factors.
RESULTS:Among 2,021 men (1,048 with HIV), baseline median age was 52 (IQR 46, 58) years; 636 were consistent, 398 intermittent, and 987 never statin users. There was a significant interaction between age, statin and HIV serostatus for gait speed. Among PWH, for every 5-year age increase, gait speed (m/sec) decline was marginally greater among consistent verses never statin users (-0.008 [95% CI -0.017, -0.00007]; p=0.048), with more notable differences between intermittent and never users (-0.017 [95% CI -0.027, -0.008]; p<0.001). Similar results were observed among men without HIV. Significant differences in grip strength (kg) decline were seen between intermittent and never users (-0.53 [95% CI -0.98, -0.07]; p=0.024), differences between consistent and never users (-0.28 [95% CI -0.63, 0.06]; p=0.11) were not statistically significant.
CONCLUSION:Among men with and without HIV, intermittent statin users had more pronounced declines in physical function compared to consistent and never users. Consistent statin use does not appear to have a major impact on physical function in men with or without HIV.</abstract><cop>United States</cop><pub>JAIDS Journal of Acquired Immune Deficiency Syndromes</pub><pmid>33230030</pmid><doi>10.1097/QAI.0000000000002579</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Ovid Lippincott Williams and Wilkins Journal Legacy Archive; MEDLINE; Free E- Journals |
| subjects | Cohort Studies Hand Strength HIV Infections - complications Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipidemias - drug therapy Male Middle Aged Physical Functional Performance |
| title | Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study |
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