Effect of Statin Therapy on Age-Associated Changes in Physical Function Among Men With and Without HIV in the Multicenter AIDS Cohort Study

BACKGROUND:The longer-term risks of statins on physical function among people with HIV are unclear. METHODS:Longitudinal analysis of Multicenter AIDS Cohort Study (MACS) men between 40-75 years of age with ≥2 measures of gait speed or grip strength. Generalized estimating equations with interaction terms between 1) statin use and age and 2) HIV serostatus, age and statin use were considered to evaluate associations between statin use and physical function. Models were adjusted for demographics and cardiovascular risk factors. RESULTS:Among 2,021 men (1,048 with HIV), baseline median age was 52 (IQR 46, 58) years; 636 were consistent, 398 intermittent, and 987 never statin users. There was a significant interaction between age, statin and HIV serostatus for gait speed. Among PWH, for every 5-year age increase, gait speed (m/sec) decline was marginally greater among consistent verses never statin users (-0.008 [95% CI -0.017, -0.00007]; p=0.048), with more notable differences between intermittent and never users (-0.017 [95% CI -0.027, -0.008]; p