SARS-CoV-2 and Dengue virus co-infection: A case from North Caribbean Colombia

[...]at a clinical level, the endotheliotropic nature of DENV and SARS-CoV-2, as well as their shared pathophysiological mechanism involving an immune mediated cytokine storm among a wide constellation of other systemic drivers, further exacerbate the clinical mimics between both pathogens, making it hard to differentiate from a clinical diagnostic standpoint. [...]findings may be explained in part by the opposed pro and anticoagulant states triggered by SARS-CoV-2 and DENV respectively, as well as to other potential causes such as viral interference [5]. [...]computational docking studies have shown that human DENV antibodies can bind to the receptor-binding (RBD) domain of SARS-CoV-2 spike protein conferring some degree of protection leading to reduced disease severity [6]. [...]from a laboratory perspective, serological cross-reactivity has become an ever-increasing challenge in DENV endemic regions, leading to a potential number of false-positives [6].