Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?

Purpose Adenocarcinoma of the salivary glands is of low incidence and a broad range of histopathological subtypes. Cancer stem cell markers (CSC) might serve as novel prognostic parameters. To date, only a few studies examined the expression of CSC in adenocarcinoma of the salivary glands with diver...

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Veröffentlicht in:European archives of oto-rhino-laryngology 2021-07, Vol.278 (7), p.2517-2528
Hauptverfasser: Spiegel, Jennifer L., Jakob, Mark, Kruizenga, Marie, Freytag, Saskia, Bertlich, Mattis, Canis, Martin, Ihler, Friedrich, Haubner, Frank, Kitz, Julia, Weiss, Bernhard G.
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Sprache:eng
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Zusammenfassung:Purpose Adenocarcinoma of the salivary glands is of low incidence and a broad range of histopathological subtypes. Cancer stem cell markers (CSC) might serve as novel prognostic parameters. To date, only a few studies examined the expression of CSC in adenocarcinoma of the salivary glands with diverging results. To further investigate the reliability in terms of prognostic value, a histopathological analysis of CSCs on a cohort of patients with adenocarcinomas of the major salivary glands was performed. Methods Tumor samples of 40 consecutive patients with adenocarcinoma of the major salivary gland treated with curative intend at one tertiary center were stained with the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2. Expression of these markers was correlated with clinicopathological parameters and survival estimates. Results Correlation of high expression of ALDH1 with higher grading ( p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-020-06389-7