Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

Tissue samples of arteriovenous malformations of the brain were obtained from 72 patients. The majority of the samples had an activating mutation in KRAS, a gene previously implicated in tumorigenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-01, Vol.378 (3), p.250-261
Hauptverfasser:	Nikolaev, Sergey I, Vetiska, Sandra, Bonilla, Ximena, Boudreau, Emilie, Jauhiainen, Suvi, Rezai Jahromi, Behnam, Khyzha, Nadiya, DiStefano, Peter V, Suutarinen, Santeri, Kiehl, Tim-Rasmus, Mendes Pereira, Vitor, Herman, Alexander M, Krings, Timo, Andrade-Barazarte, Hugo, Tung, Takyee, Valiante, Taufik, Zadeh, Gelareh, Tymianski, Mike, Rauramaa, Tuomas, Ylä-Herttuala, Seppo, Wythe, Joshua D, Antonarakis, Stylianos E, Frösen, Juhana, Fish, Jason E, Radovanovic, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Arteries Brain Brain research Children Deoxyribonucleic acid DNA DNA sequencing Endothelial cells Extracellular signal-regulated kinase Gene expression Genetic testing Hemorrhage K-Ras protein MAP kinase Mutation Neurosciences Neurosurgery Notch protein Pathology Patients Protein kinase Signal transduction Stroke Veins & arteries
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Beschreibung
Zusammenfassung:	Tissue samples of arteriovenous malformations of the brain were obtained from 72 patients. The majority of the samples had an activating mutation in KRAS, a gene previously implicated in tumorigenesis.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1709449