Long Non-Coding RNA MEG3 in Cellular Stemness
Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This revie...
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| Veröffentlicht in: | International journal of molecular sciences 2021-05, Vol.22 (10), p.5348 |
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| container_title | International journal of molecular sciences |
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| creator | Hsieh, Pei-Fang Yu, Cheng-Chia Chu, Pei-Ming Hsieh, Pei-Ling |
| description | Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This review focuses on the molecular mechanisms by which lncRNA MEG3 functions as a signal, scaffold, guide, and decoy for multi-lineage differentiation and even cancer progression. The role of MEG3 in various types of stem cells and cancer stem cells is discussed. Here, we provide an overview of the functional versatility of lncRNA MEG3 in modulating pluripotency, differentiation, and cancer stemness. |
| doi_str_mv | 10.3390/ijms22105348 |
| format | Article |
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| subjects | Apoptosis Binding sites Bone marrow Cancer Differentiation DNA methylation Epigenetics Gene expression Growth factors Kinases MicroRNAs Molecular modelling Nervous system Non-coding RNA Pluripotency Post-transcription Post-translation Proteins Review Senescence Stem cells Translation |
| title | Long Non-Coding RNA MEG3 in Cellular Stemness |
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