Long Non-Coding RNA MEG3 in Cellular Stemness

Long Non-Coding RNA MEG3 in Cellular Stemness

Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This revie...

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Veröffentlicht in:International journal of molecular sciences 2021-05, Vol.22 (10), p.5348
Hauptverfasser: Hsieh, Pei-Fang, Yu, Cheng-Chia, Chu, Pei-Ming, Hsieh, Pei-Ling
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Binding sites
Bone marrow
Cancer
Differentiation
DNA methylation
Epigenetics
Gene expression
Growth factors
Kinases
MicroRNAs
Molecular modelling
Nervous system
Non-coding RNA
Pluripotency
Post-transcription
Post-translation
Proteins
Review
Senescence
Stem cells
Translation
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Zusammenfassung:Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This review focuses on the molecular mechanisms by which lncRNA MEG3 functions as a signal, scaffold, guide, and decoy for multi-lineage differentiation and even cancer progression. The role of MEG3 in various types of stem cells and cancer stem cells is discussed. Here, we provide an overview of the functional versatility of lncRNA MEG3 in modulating pluripotency, differentiation, and cancer stemness.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22105348